Association between trough plasma voriconazole concentration and adverse drug reactions in elderly patients.

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY International journal of clinical pharmacology and therapeutics Pub Date : 2024-10-16 DOI:10.5414/CP204547

Xiaolei Hu, Min Tang, Ling Tang, Xiaofei Liu, Lu Chen, Jun Zhou

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Abstract

Objective: Only limited data are available on trough plasma voriconazole concentration in elderly patients. This study aimed to assess the association between voriconazole concentration and adverse drug reactions (ADR).

Materials and methods: A retrospective analysis was conducted to investigate the correlation between voriconazole trough concentration and adverse reactions among elderly patients admitted between October 1, 2017, and September 30, 2020.

Results: In total 147 patients were included in this study, with 248 measurements of voriconazole concentrations available. ADR occurred in 75 patients after drug therapy, with liver injury showing the highest incidence (n = 37, 49.33%), followed by hypokalemia (n = 27, 36%), and neurological disorder (n = 20, 26.67%). 121 measurements (48.79%) in 82 patients (55.78%) showed that the monitored trough concentration did not match the occurrence of ADR, mainly including hyponatremia, hypokalemia, liver injury, and kidney injury.

Conclusion: The accuracy of predicting the trough concentration of voriconazole as recommended by current guidelines for elderly patients might be limited. Consequently, it is advisable to establish a tailored treatment range of voriconazole concentration specifically catered to this patient demographic.

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老年患者血浆伏立康唑谷值浓度与药物不良反应之间的关系。

目的：关于老年患者血浆伏立康唑谷值浓度的数据十分有限。本研究旨在评估伏立康唑浓度与药物不良反应（ADR）之间的关联：对2017年10月1日至2020年9月30日期间收治的老年患者中伏立康唑谷浓度与不良反应的相关性进行回顾性分析：本研究共纳入147名患者，共测量了248次伏立康唑浓度。75名患者在药物治疗后发生了ADR，其中肝损伤发生率最高（n = 37，49.33%），其次是低钾血症（n = 27，36%）和神经系统紊乱（n = 20，26.67%）。82名患者（55.78%）的121次测量结果（48.79%）显示，监测到的谷浓度与ADR的发生不匹配，主要包括低钠血症、低钾血症、肝损伤和肾损伤：结论：根据现行指南的建议，预测老年患者服用伏立康唑的谷浓度的准确性可能有限。结论：根据目前的指南建议，预测老年患者的伏立康唑谷值浓度的准确性可能有限，因此，最好制定一个专门针对老年患者的伏立康唑浓度治疗范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of clinical pharmacology and therapeutics 医学-药学

CiteScore

1.70

自引率

12.50%

发文量

116

审稿时长

4-8 weeks

期刊介绍： The International Journal of Clinical Pharmacology and Therapeutics appears monthly and publishes manuscripts containing original material with emphasis on the following topics: Clinical trials, Pharmacoepidemiology - Pharmacovigilance, Pharmacodynamics, Drug disposition and Pharmacokinetics, Quality assurance, Pharmacogenetics, Biotechnological drugs such as cytokines and recombinant antibiotics. Case reports on adverse reactions are also of interest.