Near-Infrared Driven Gold Nanoparticles-Decorated g-C₃N₄/SnS₂ Heterostructure through Photodynamic and Photothermal Therapy for Cancer Treatment.

IF 6.6 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY International Journal of Nanomedicine Pub Date : 2024-10-17 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S478883

Pranjyan Dash, Senthilkumar Thirumurugan, Nandini Nataraj, Yu-Chien Lin, Xinke Liu, Udesh Dhawan, Ren-Jei Chung

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Abstract

Background: Phototherapy based on photocatalytic semiconductor nanomaterials has received considerable attention for the cancer treatment. Nonetheless, intense efficacy for in vivo treatment is restricted by inadequate photocatalytic activity and visible light response.

Methods: In this study, we designed a photocatalytic heterostructure using graphitic carbon nitride (g-C₃N₄) and tin disulfide (SnS₂) to synthesize g-C₃N₄/SnS₂ heterostructure through hydrothermal process. Furthermore, Au nanoparticles were decorated in situ deposition on the surface of the g-C₃N₄/SnS₂ heterostructure to form g-C₃N₄/SnS₂@Au nanoparticles.

Results: The g-C₃N₄/SnS₂@Au nanoparticles generated intense reactive oxygen species radicals under near-infrared (NIR) laser irradiation through photodynamic therapy (PDT) pathways (Type-I and Type-II). These nanoparticles exhibited enhanced photothermal therapy (PTT) efficacy with high photothermal conversion efficiency (41%) when subjected to 808 nm laser light, owing to the presence of Au nanoparticles. The in vitro studies have indicated that these nanoparticles can induce human liver carcinoma cancer cell (HepG2) apoptosis (approximately 80% cell death) through the synergistic therapeutic effects of PDT and PTT. The in vivo results demonstrated that these nanoparticles exhibited enhanced efficient antitumor effects based on the combined effects of PDT and PTT.

Conclusion: The g-C₃N₄/SnS₂@Au nanoparticles possessed enhanced photothermal properties and PDT effect, good biocompatibility and intense antitumor efficacy. Therefore, these nanoparticles could be considered promising candidates through synergistic PDT/PTT effects upon irradiation with NIR laser for cancer treatment.

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通过光动力和光热疗法治疗癌症的近红外驱动金纳米颗粒装饰 g-C3N4/SnS2 异质结构。

背景：基于光催化半导体纳米材料的光疗法在癌症治疗中受到广泛关注。然而，由于光催化活性和可见光响应不足，体内治疗的强效性受到限制：本研究利用氮化石墨（g-C3N4）和二硫化锡（SnS2）设计了一种光催化异质结构，通过水热法合成了 g-C3N4/SnS2 异质结构。此外，在 g-C3N4/SnS2 异质结构表面原位沉积金纳米粒子，形成 g-C3N4/SnS2@Au 纳米粒子：g-C3N4/SnS2@Au 纳米粒子在近红外（NIR）激光照射下通过光动力疗法（PDT）途径（I 型和 II 型）产生强烈的活性氧自由基。由于金纳米粒子的存在，这些纳米粒子在 808 纳米激光照射下表现出更强的光热疗法（PTT）功效，光热转换效率高达 41%。体外研究表明，这些纳米颗粒可通过光动力疗法和光热疗法的协同治疗效应诱导人肝癌癌细胞（HepG2）凋亡（约 80% 的细胞死亡）。体内研究结果表明，这些纳米粒子在 PDT 和 PTT 的联合作用下表现出更高效的抗肿瘤效果：结论：g-C3N4/SnS2@金纳米粒子具有增强的光热特性和PDT效应、良好的生物相容性和强大的抗肿瘤功效。因此，这些纳米粒子在近红外激光照射下具有PDT/PTT协同效应，有望用于癌症治疗。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.