Fe-HCOF-PEG²⁰⁰⁰ as a Hypoxia-Tolerant Photosensitizer to Trigger Ferroptosis and Enhance ROS-Based Cancer Therapy.

IF 6.6 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY International Journal of Nanomedicine Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S479848

Hui Peng, Qian Jiang, Wenhao Mao, Zhonglan Hu, Qi Wang, Zhuo Yu, Li Zhang, Xinyan Wang, Chunbo Zhuang, Jia Mai, Zhiyuan Wang, Ting Sun

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Abstract

Background: The hypoxic tumor microenvironment and single mechanisms severely limit the photodynamic therapy (PDT) efficiency of covalent organic framework (COF) nanoparticles in cancer treatment.

Purpose: Here, we propose an iron-loaded, hydrophilic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000)-modified hollow covalent organic framework (HCOF), Fe-HCOF-PEG²⁰⁰⁰, for use in hypoxic PDT and ferroptosis therapy owing to its type I and II photodynamic ability and iron nanoparticle loading property.

Results: Fe-HCOF-PEG²⁰⁰⁰ nanoparticles (Fe-HCOFs-PEG²⁰⁰⁰) with semiconducting polymers and microporous skeletons allow efficient photophysical properties. Moreover, the iron nanoparticles on Fe-HCOF-PEG²⁰⁰⁰ caused ferroptosis and further enhanced tumor elimination under normoxic and hypoxic conditions. DSPE-PEG²⁰⁰⁰ endowed Fe-HCOF-PEG²⁰⁰⁰ with hydrophilicity, allowing it to circulate and accumulate in organs rich in blood supply, especially tumors. 808 nm NIR activated Fe-HCOF-PEG²⁰⁰⁰ aggregated in tumors and significantly inhibited tumor growth under hypoxia.

Conclusion: To our knowledge, Fe-HCOF-PEG²⁰⁰⁰ is the leading combination of type I/II PDT and ferroptosis. The strong antitumor effects of this nanomaterial suggest prospects for clinical translation as a tumor nanotherapy drug.

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Fe-HCOF-PEG2000作为一种耐缺氧光敏剂，可触发铁跃迁并增强基于 ROS 的癌症疗法。

背景：缺氧的肿瘤微环境和单一机制严重限制了共价有机框架（COF）纳米粒子在癌症治疗中的光动力疗法（PDT）效率。目的：在此，我们提出了一种铁负载的亲水性 1,2-二硬脂酰-sn-甘油-3-磷乙醇胺-N-[甲氧基（聚乙二醇）-2000]（DSPE-PEG2000）修饰的中空共价有机框架（HCOF）--Fe-HCOF-PEG2000，由于其 I 型和 II 型光动力能力以及铁纳米粒子负载特性，该纳米粒子可用于缺氧光动力疗法和铁跃迁疗法：结果：具有半导体聚合物和微孔骨架的 Fe-HCOF-PEG2000 纳米粒子（Fe-HCOFs-PEG2000）具有高效的光物理特性。此外，Fe-HCOF-PEG2000 上的铁纳米粒子还能引起铁突变，并进一步增强常氧和缺氧条件下的肿瘤消除能力。DSPE-PEG2000 赋予了 Fe-HCOF-PEG2000 亲水性，使其能够在血液供应丰富的器官，尤其是肿瘤中循环和积聚。808 纳米近红外激活的 Fe-HCOF-PEG2000 在肿瘤中聚集，并在缺氧条件下显著抑制肿瘤生长：据我们所知，Fe-HCOF-PEG2000 是 I/II 型 PDT 和铁氧体渗透的主要组合。结论：据我们所知，Fe-HCOF-PEG2000 是 I/II 型 PDT 和铁氧体凋亡的主要组合，这种纳米材料的强大抗肿瘤作用表明它有望作为一种肿瘤纳米治疗药物应用于临床。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.