Temporal Changes in the Retinal Pigment Epithelium-Bruch's Membrane Complex Thickness After Autologous Retinal Transplantation in Myopic Eyes.

IF 5 2区 医学 Q1 OPHTHALMOLOGY Investigative ophthalmology & visual science Pub Date : 2024-10-01 DOI:10.1167/iovs.65.12.25
Shohei Kitahata, Tatsuya Inoue, Shin Tanaka, Jacob Y H Chin, Satoru Shinoda, Maiko Maruyama-Inoue, Kazuaki Kadonosono
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Abstract

Purpose: To investigate the association between the thickness of the retinal pigment epithelium (RPE)-Bruch's membrane (BM) complex and the development of retinal autograft edema as a postoperative complication following autologous retinal transplantation (ART).

Methods: This retrospective study examined data from 28 eyes of 28 patients (14 males, 14 females; mean age, 61.5 ± 19.8 years) who underwent ART and were followed for 1 year. The RPE-BM complex thickness was measured 2000 µm from the fovea using Image J software. Additionally, the graft blood flow was also evaluated by optical coherence tomography angiography and fluorescein angiography.

Results: Macular hole (MH) diameters ranged from 711.2 ± 251.9 µm to 1299.9 ± 333.0 µm, with MH closure achieved in all patients. RPE-BM complex thickness decreased by 4.17 µm at 6 months and 4.34 µm at 1 year, showing significant differences from preoperative measurements (29.88 ± 4.99 µm; 6 months: 95% confidence interval [CI], 1.62-6.71, P = 0.0018; 1 year: 95% CI, 2.03-6.65 µm, P = 0.00044). The decrease was significantly greater in the edema-positive group (95% CI, -8.33 to -0.82, P = 0.020). Furthermore, the rates of ellipsoid zone (EZ) recovery, alignment of neurosensory layers (ANL), and graft reperfusion were lower in the edema-positive group (EZ, P = 0.017; ANL, P = 0.0098; reperfusion, P = 0.039).

Conclusions: After ART, RPE-BM complex thickness decreases, particularly in cases with postoperative edema, suggesting a potential relationship between RPE function and postoperative outcomes, highlighting the importance of monitoring RPE-BM complex thickness after surgery.

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近视眼自体视网膜移植后视网膜色素上皮-布氏膜复合厚度的时间变化
目的:研究视网膜色素上皮(RPE)-布鲁氏膜(BM)复合体的厚度与自体视网膜移植(ART)术后并发症--视网膜自体移植物水肿之间的关系:这项回顾性研究检查了接受自体视网膜移植手术并随访一年的 28 位患者(男性 14 位,女性 14 位;平均年龄 61.5 ± 19.8 岁)的 28 只眼睛的数据。使用 Image J 软件测量了距离眼窝 2000 µm 的 RPE-BM 复合物厚度。此外,还通过光学相干断层扫描血管造影术和荧光素血管造影术评估了移植物血流:黄斑孔(MH)直径从 711.2 ± 251.9 µm 到 1299.9 ± 333.0 µm 不等,所有患者都实现了黄斑孔闭合。RPE-BM 复合物厚度在 6 个月时减少了 4.17 µm,在 1 年时减少了 4.34 µm,与术前测量值相比差异显著(29.88 ± 4.99 µm;6 个月:95% 置信区间 [CI];1 年:95% 置信区间 [CI]):6 个月:95% 置信区间 [CI],1.62-6.71,P = 0.0018;1 年:95% CI,2.03-6.65 µm,P = 0.00044)。水肿阳性组的下降幅度明显更大(95% CI,-8.33 至 -0.82,P = 0.020)。此外,水肿阳性组的椭圆体区(EZ)恢复率、神经感觉层对齐率(ANL)和移植物再灌注率均较低(EZ,P = 0.017;ANL,P = 0.0098;再灌注,P = 0.039):ART术后,RPE-BM复合体厚度下降,尤其是术后水肿的病例,这表明RPE功能与术后结果之间存在潜在关系,突出了术后监测RPE-BM复合体厚度的重要性。
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来源期刊
CiteScore
6.90
自引率
4.50%
发文量
339
审稿时长
1 months
期刊介绍: Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.
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