Longitudinal lipidomic profiles of left ventricular mass and hypertrophy in American Indians.

IF 6.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL JCI insight Pub Date : 2024-10-15 DOI:10.1172/jci.insight.181172
Mingjing Chen, Zhijie Huang, Guanhong Miao, Jin Ren, Jinling Liu, Mary J Roman, Richard B Devereux, Richard R Fabsitz, Ying Zhang, Jason G Umans, Shelley A Cole, Tanika N Kelly, Oliver Fiehn, Jinying Zhao
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Abstract

Left ventricular hypertrophy (LVH) and dyslipidemia are strong, independent predictors for cardiovascular disease, but their relationship is less well-studied. A longitudinal lipidomic profiling of left ventricular mass (LVM) and LVH is still lacking. Using LC-MS, we repeatedly measured 1,542 lipids from 1,755 unique American Indians attending two exams (mean~5-year apart). Cross-sectional associations of individual lipid species with LVM index (LVMI) were examined by generalized estimating equation (GEE), followed by replication in an independent bi-racial cohort (65% white, 35% black). Baseline plasma lipids associated with LVH risk beyond traditional risk factors were identified by Cox frailty model in American Indians. Longitudinal associations between changes in lipids and changes in LVMI were examined by GEE, adjusting for baseline lipids, baseline LVMI, and covariates. Multiple lipid species (e.g., glycerophospholipids, sphingomyelins, acylcarnitines) were significantly associated with LVMI or the risk of LVH in American Indians. Some lipids were confirmed in black and white individuals. Moreover, some LVH-related lipids were inversely associated with risk of coronary heart disease (CHD). Longitudinal changes in several lipid species (e.g., glycerophospholipids, sphingomyelins, cholesterol esters) were significantly associated with changes in LVMI. These findings provide insights into the role of lipid metabolism in LV remodeling and the risk of LVH or CHD.

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美国印第安人左心室质量和肥厚的纵向脂质体特征。
左心室肥厚(LVH)和血脂异常是心血管疾病强有力的独立预测因素,但对它们之间的关系研究较少。目前还缺乏对左心室质量(LVM)和左心室肥厚的纵向脂质体分析。利用 LC-MS,我们对参加两次体检(平均相隔约 5 年)的 1,755 名独特的美国印第安人的 1,542 种脂质进行了反复测量。通过广义估计方程(GEE)检验了单个血脂种类与 LVM 指数(LVMI)的横断面关联,随后在一个独立的双种族队列(65% 白人,35% 黑人)中进行了复制。在美国印第安人中,通过 Cox 脆弱性模型确定了与 LVH 风险相关的基线血浆脂质,而非传统的风险因素。通过 GEE 检验了血脂变化与 LVMI 变化之间的纵向联系,并对基线血脂、基线 LVMI 和协变量进行了调整。多种脂质(如甘油磷脂、鞘磷脂、酰基肉碱)与美国印第安人的 LVMI 或 LVH 风险显著相关。一些血脂在黑人和白人中得到证实。此外,一些与左心室肥厚相关的脂质与冠心病(CHD)风险成反比。几种脂质(如甘油磷脂、鞘磷脂、胆固醇酯)的纵向变化与 LVMI 的变化显著相关。这些发现为脂质代谢在左心室重塑和左心室肥厚或冠心病风险中的作用提供了见解。
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来源期刊
JCI insight
JCI insight Medicine-General Medicine
CiteScore
13.70
自引率
1.20%
发文量
543
审稿时长
6 weeks
期刊介绍: JCI Insight is a Gold Open Access journal with a 2022 Impact Factor of 8.0. It publishes high-quality studies in various biomedical specialties, such as autoimmunity, gastroenterology, immunology, metabolism, nephrology, neuroscience, oncology, pulmonology, and vascular biology. The journal focuses on clinically relevant basic and translational research that contributes to the understanding of disease biology and treatment. JCI Insight is self-published by the American Society for Clinical Investigation (ASCI), a nonprofit honor organization of physician-scientists founded in 1908, and it helps fulfill the ASCI's mission to advance medical science through the publication of clinically relevant research reports.
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