Comparing the effect of sedation with dexmedetomidine and propofol on sleep quality of patients after cardiac surgery: A randomized clinical trial.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2024-09-20 DOI:10.34172/jcvtr.33086

Rasoul Azarfarin, Mohsen Ziaei Fard, Maryam Ghadimi, Yasmin Chaibakhsh, Marziyeh Yousefi

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Abstract

Introduction: Sleep quality is the main concern of patients after cardiac surgery. We compared the effect of two routinely used sedatives on the sleep quality of patients admitted to the intensive care unit (ICU) after cardiovascular surgery.

Methods: It is a prospective, controlled, randomized clinical trial. A total of 120 patients, after cardiac surgery were enrolled. During extubating, patients were randomized into two groups: 60 patients received an infusion of dexmedetomidine (precede; 0.5 μg/kg/h), and 60 patients received 50 μg/kg/min propofol for 6 hours. Baseline characteristics were compared between the groups. The patients completed the St. Mary's Hospital Sleep Questionnaire, and the scores were compared between the groups.

Results: The groups were not different in terms of demographics, underlying diseases, smoking/drug abuse/alcohol, number of vessels involved, history of non-cardiac surgery, and mean levels of serum parameters (P>0.05). Most of the medications used were similar between the groups (P>0.05), except calcium channel blockers (more frequently used in the propofol group [P=0.027). The details of surgery were not statistically significant different (P>0.05); but, the mean volume of platelet received after the surgery was higher in propofol group (P=0.03). The propofol group had less problems with last night's sleep (0 vs 0.1±0.66), felt more clear-headed (4.9±0.6 vs 4.68±0.58, were more satisfied with their last night's sleep (52.1% vs 47.9%), but spent more time getting into sleep (0.38±1.67 vs 0 ) (P<0.5).

Conclusion: The sleep quality of patients under the influence of propofol seemed to be better than dexmedetomidine after cardiac surgery.

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比较右美托咪定和异丙酚镇静对心脏手术后患者睡眠质量的影响：随机临床试验。

导言睡眠质量是心脏手术后患者最关心的问题。我们比较了两种常规镇静剂对心血管手术后入住重症监护室（ICU）的患者睡眠质量的影响：这是一项前瞻性、对照、随机临床试验。共有 120 名心脏手术后的患者参加了该试验。在拔管期间，患者被随机分为两组：60 名患者接受右美托咪定输注（precede；0.5 μg/kg/h），60 名患者接受 50 μg/kg/min 异丙酚输注，持续 6 小时。两组患者的基线特征进行了比较。患者填写了圣玛丽医院睡眠问卷，并对各组的得分进行了比较：结果：两组患者在人口统计学、基础疾病、吸烟/酗酒/吸毒、受累血管数量、非心脏手术史和血清参数平均水平等方面均无差异（P>0.05）。除钙通道阻滞剂（异丙酚组更常用[P=0.027]）外，两组使用的大多数药物相似（P>0.05）。手术细节差异无统计学意义（P>0.05）；但异丙酚组术后获得的血小板平均量更高（P=0.03）。丙泊酚组患者昨晚的睡眠问题较少（0 vs 0.1±0.66），感觉头脑更清醒（4.9±0.6 vs 4.68±0.58），对昨晚的睡眠更满意（52.1% vs 47.9%），但进入睡眠状态花费的时间较长（0.38±1.67 vs 0）（结论：丙泊酚组患者的睡眠质量高于丙泊酚组：心脏手术后使用异丙酚的患者的睡眠质量似乎优于右美托咪定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.