Regenerative Endodontic Procedures With Minced Pulp Tissue Graft in Mature Permanent Teeth: A Clinical Study.

IF 3.5 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of endodontics Pub Date : 2024-10-12 DOI:10.1016/j.joen.2024.10.004
Ukseong Kim, Sunil Kim, Stephanie Myeong Choi, Mo K Kang, Insoon Chang, Euiseong Kim
{"title":"Regenerative Endodontic Procedures With Minced Pulp Tissue Graft in Mature Permanent Teeth: A Clinical Study.","authors":"Ukseong Kim, Sunil Kim, Stephanie Myeong Choi, Mo K Kang, Insoon Chang, Euiseong Kim","doi":"10.1016/j.joen.2024.10.004","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Regenerative endodontic procedures (REPs) using cell-based approaches have emerged as novel treatment modalities. This clinical study aimed to present the outcomes and explore factors influencing REPs with minced pulp tissue (MP) grafts in a mature tooth.</p><p><strong>Methods: </strong>Healthy patients requiring non-surgical root canal treatment were enrolled. MP obtained from the third molar was grafted into the instrumented, disinfected, and blood-filled root canal. After treatment, patients were evaluated clinically and radiographically.</p><p><strong>Results: </strong>Follow-ups for 6 cases (male patients aged 20-27) ranged from 19 to 42 months. Radiographically, all the teeth showed favorable outcomes. Among the 6 teeth, 2 showed neither intracanal calcification nor recovery in sensibility tests, and one had no intracanal calcification with an inapplicable sensibility test evaluation. In 2 teeth, intracanal calcification was observed in the apical third; however, there was no recovery in the sensibility tests. One tooth exhibited intracanal calcification in the apical third and showed recovery in the sensibility tests. Considering these outcomes and clinical variables, the size of the apical foramen and the composition of the transplanted pulp tissue were identified as tentative influencing factors.</p><p><strong>Conclusions: </strong>This exploratory clinical study on simplified cell-based REPs using autologous MP grafts for pulp/dentin regeneration in adult teeth not only enhances our understanding of REPs but also suggests its potential as an alternative treatment option to conventional endodontic treatment.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of endodontics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.joen.2024.10.004","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Regenerative endodontic procedures (REPs) using cell-based approaches have emerged as novel treatment modalities. This clinical study aimed to present the outcomes and explore factors influencing REPs with minced pulp tissue (MP) grafts in a mature tooth.

Methods: Healthy patients requiring non-surgical root canal treatment were enrolled. MP obtained from the third molar was grafted into the instrumented, disinfected, and blood-filled root canal. After treatment, patients were evaluated clinically and radiographically.

Results: Follow-ups for 6 cases (male patients aged 20-27) ranged from 19 to 42 months. Radiographically, all the teeth showed favorable outcomes. Among the 6 teeth, 2 showed neither intracanal calcification nor recovery in sensibility tests, and one had no intracanal calcification with an inapplicable sensibility test evaluation. In 2 teeth, intracanal calcification was observed in the apical third; however, there was no recovery in the sensibility tests. One tooth exhibited intracanal calcification in the apical third and showed recovery in the sensibility tests. Considering these outcomes and clinical variables, the size of the apical foramen and the composition of the transplanted pulp tissue were identified as tentative influencing factors.

Conclusions: This exploratory clinical study on simplified cell-based REPs using autologous MP grafts for pulp/dentin regeneration in adult teeth not only enhances our understanding of REPs but also suggests its potential as an alternative treatment option to conventional endodontic treatment.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
在成熟恒牙中使用粉碎的牙髓组织移植进行牙髓再生手术:临床研究。
简介:使用基于细胞的方法进行牙髓再生治疗(REPs)已成为一种新的治疗模式。本临床研究旨在介绍在成熟牙中使用碎牙髓组织(MP)移植进行牙髓再生治疗的结果,并探讨影响其结果的因素:本研究选取了六名需要进行非手术根管治疗的 20-27 岁健康男性患者。将从第三磨牙上获取的骨髓组织引入经过器械处理、消毒和充血的根管中。用生物陶瓷水门汀封闭根管,并修复冠状通路腔:六个病例的随访时间从 19 个月到 42 个月不等。所有牙齿的影像学结果均良好。在这六颗牙齿中,有两颗既没有出现牙槽骨内钙化,也没有在敏感性测试中得到恢复,有一颗没有出现牙槽骨内钙化,但敏感性测试评估不适用。有两颗牙齿的根尖三分之一处出现牙槽骨内钙化,但在感度测试中没有恢复。有一颗牙齿的根尖三分之一处出现了牙槽骨内钙化,但在感度测试中显示已经恢复。考虑到这些结果和临床变量,根尖孔的大小和移植牙髓组织的成分被确定为初步的影响因素:这项关于使用自体 MP 进行成人牙髓/牙本质再生的简化细胞疗法的研究不仅加深了我们对 REPs 的理解,还表明它有可能成为传统牙髓治疗的替代治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of endodontics
Journal of endodontics 医学-牙科与口腔外科
CiteScore
8.80
自引率
9.50%
发文量
224
审稿时长
42 days
期刊介绍: The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.
期刊最新文献
Effect of preoperative oral cannabidiol-rich Cannabis extract on anxiety and postoperative pain after endodontic treatment: A double-blind randomized clinical trial. The effect of different separated file retrieval strategies on the biomechanical behavior of a mandibular molar: a finite element analysis study. Comparative Analysis of Temperature Changes with Preheated and Intracanal Heated Solutions and Ultrasonic Activation in Immature Teeth. Insights Into the November 2024 Issue of the Journal of Endodontics. Cone-Beam Computed Tomographic Scan-based Assessment of the Correlation between the Location of Caries and Pulp Canal Obliteration: An Aid to Treatment Planning.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1