No impact of a positive Chlamydia trachomatis serology on live-birth rate after intra-uterine insemination

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY Journal of gynecology obstetrics and human reproduction Pub Date : 2024-10-16 DOI:10.1016/j.jogoh.2024.102863

Virginie Trabaud , Laura Miquel , Cindy Faust , Julie Berbis , Odile Paulmyer-Lacroix , Blandine Courbiere

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Abstract

Objective

To study the impact of a CT serology on intrauterine insemination (IUI) cumulative live-birth rate (cLBR) in women with documented bilateral tubal patency.

Design

Cohort study

Subjects

Infertile women with documented bilateral tubal patency and medical indication of IUI matched on the following criteria: woman's age, number of cycles completed and number of motile sperm inseminated (NMSI).

Exposure

This retrospective, observational and monocentric cohort study compared women with positive CT serology matched 1:1 to control women with negative CT serology.

Main outcome measures

Cumulative LBR, rates of clinical pregnancy, spontaneous abortion, biochemical pregnancy.

Results

A total of 71 women in the CT positive group were matched to 71 women in the negative CT group, leading to compare 136 cycles per group. No statistically significant difference was observed between groups regarding the demographic and medical characteristics of couples. Cumulative LBR per woman was similar in both groups with 32.4% (n = 23) in the negative serology group Vs 25.4% (n = 18) in the positive CT group (NS). The rates of clinical pregnancy, spontaneous abortion, biochemical pregnancy were comparable between the two groups.

Conclusion

In a population of infertile women with patent tubes, our study suggests that the serological status for CT has no impact on the IIU cLBR.

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沙眼衣原体血清阳性对宫腔内人工授精后的活产率没有影响。

目的研究 CT 血清学对双侧输卵管通畅妇女宫腔内人工授精（IUI）累积活产率（cLBR）的影响：队列研究：暴露：这项回顾性、观察性和单中心队列研究将 CT 血清学阳性的妇女与 CT 血清学阴性的对照妇女进行 1:1 比对：主要结果测量指标：累积 LBR、临床妊娠率、自然流产率、生化妊娠率：CT 阳性组中的 71 名妇女与 CT 阴性组中的 71 名妇女进行了配对，从而比较了每组 136 个周期。在夫妇的人口学和医学特征方面，各组之间没有发现明显的统计学差异。两组妇女的累积 LBR 相似，血清学阴性组为 32.4%（n = 23），而 CT 阳性组为 25.4%（n = 18）（NS）。两组的临床妊娠率、自然流产率和生化妊娠率相当：我们的研究表明，在输卵管通而不畅的不孕妇女群体中，CT 血清学状态对 IIU cLBR 没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of gynecology obstetrics and human reproduction Medicine-Obstetrics and Gynecology

CiteScore

3.70

自引率

5.30%

发文量

210

审稿时长

31 days

期刊介绍： Formerly known as Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Journal of Gynecology Obstetrics and Human Reproduction is the official Academic publication of the French College of Obstetricians and Gynecologists (Collège National des Gynécologues et Obstétriciens Français / CNGOF). J Gynecol Obstet Hum Reprod publishes monthly, in English, research papers and techniques in the fields of Gynecology, Obstetrics, Neonatology and Human Reproduction: (guest) editorials, original articles, reviews, updates, technical notes, case reports, letters to the editor and guidelines. Original works include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.

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