Association of four CTLA-4 gene polymorphisms with pemphigus risk: a systematic review, meta-analysis, and meta-regression.

IF 1.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Journal of International Medical Research Pub Date : 2024-10-01 DOI:10.1177/03000605241282116

Tarak Dhaouadi, Awatef Riahi, Taïeb Ben Abdallah, Yousr Gorgi, Imen Sfar

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Abstract

Objectives: This review aimed to summarize the existing data on the contribution of four single nucleotide polymorphisms (SNPs) in the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) genes to pemphigus susceptibility.

Methods: An electronic literature search for eligible studies among those published prior to 30 April 2024 was conducted through the PubMed, EMBASE, Web of Science, and Scopus databases. To minimize publication bias, an additional search was performed via the Google Scholar and Semantic Scholar search engines. Meta-analyses, together with subgroup analyses and meta-regressions, were performed for the following four CTLA-4 SNPs: rs231775, rs5742909, rs3087243, and rs733618.

Results: Combined analyses revealed a significant increase in pemphigus risk conferred by the CTLA-4 rs5742909*C and rs733618*C alleles. Conversely, there was no evidence of any significant association between the rs231775*G and rs3087243*G alleles and susceptibility to pemphigus. Subgroup analyses by ethnicity and pemphigus type (vulgaris or foliaceus) and meta-regressions did not reveal any significant difference.

Conclusion: This meta-analysis suggested that two of the four investigated CTLA-4 SNPs were significantly associated with increased pemphigus risk.Registration: This review has been registered on PROSPERO: CRD42024550668; available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024550668.

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四种 CTLA-4 基因多态性与天疱疮风险的关系：系统综述、荟萃分析和荟萃回归。

研究目的本综述旨在总结细胞毒性 T 淋巴细胞相关抗原-4（CTLA-4）基因中四个单核苷酸多态性（SNPs）对丘疹性荨麻疹易感性影响的现有数据：通过 PubMed、EMBASE、Web of Science 和 Scopus 数据库对 2024 年 4 月 30 日之前发表的符合条件的研究进行电子文献检索。为尽量减少发表偏差，还通过谷歌学术（Google Scholar）和语义学者（Semantic Scholar）搜索引擎进行了额外搜索。针对以下四个 CTLA-4 SNP：rs231775、rs5742909、rs3087243 和 rs733618，进行了元分析、亚组分析和元回归：结果：综合分析表明，CTLA-4 rs5742909*C 和 rs733618*C 等位基因会显著增加丘疹性荨麻疹风险。相反，没有证据表明 rs231775*G 和 rs3087243*G 等位基因与丘疹性荨麻疹的易感性有任何显著关联。按种族和丘疹性荨麻疹类型（寻常型或叶状型）进行的亚组分析以及元回归均未发现任何明显差异：这项荟萃分析表明，在所研究的四个 CTLA-4 SNPs 中，有两个与丘疹性荨麻疹风险的增加有显著相关性：本综述已在 PROSPERO 上注册：CRD42024550668；可从以下网址获取：https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024550668。

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来源期刊

Journal of International Medical Research 医学-药学

CiteScore

3.20

自引率

0.00%

发文量

555

审稿时长

1 months

期刊介绍： _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605