Evaluation of Risk Factors Associated with Recurrence and Death in Patients with Thyroid Cancer From 2008 to 2023 in the West of Iran.

IF 1.4 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of research in health sciences Pub Date : 2024-09-30 Epub Date: 2024-08-01 DOI:10.34172/jrhs.2024.167
Salman Khazaei, Soheil Abdollahi Yeganeh, Seyed Ahmad Raza Salim Bahrami, Shiva Borzouei
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Abstract

Background: Thyroid carcinoma (TC) is a global clinical concern, and its incidence has progressively increased worldwide. Early detection of TC and subsequently decreased age at the diagnosis seem to result from extensive employment of imaging modalities, biopsy techniques, and improvements in the healthcare system. Study Design: A retrospective cohort study.

Methods: Overall, 400 patients diagnosed with TC following thyroidectomy in the Endocrinology Clinic, who were followed for fifteen years, were investigated in this study. The checklist included patients' demographic characteristics, clinical information, and response to treatment, recurrence, and death.

Results: There were 19.25% men and 80.75% women. The mean age was 41.005±15.58 years. The risk of death and recurrence was significantly higher in men, patients>65 years, smokers, patients with a family history of TC, undifferentiated cancer, multifocality, and stages III and IV (P<0.001). Each additional year of life was associated with a 21% increase in the risk of death (P<0.001). Smoking was associated with a 4.36-fold increase in the risk of death (P=0.05). For each additional year of life, the probability of recurrence increased by 3% (P=0.009). Men were 4.73 times more likely to recur (P<0.001) than women.

Conclusion: To employ the proper therapeutic intervention and perform meticulous postoperative surveillance, it is crucial to consider the predictive influence of pertinent elements. Diagnosing TC in its early stages is essential for the healthcare system because of the increased incidence, younger age at diagnosis, and overall favorable prognosis of TC.

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对 2008 年至 2023 年伊朗西部甲状腺癌患者复发和死亡的相关风险因素进行评估。
背景:甲状腺癌(TC)是一个全球性的临床问题,其发病率在全球范围内逐渐上升。甲状腺癌的早期发现和确诊年龄的降低似乎得益于影像学模式、活检技术的广泛应用以及医疗保健系统的改善。研究设计:回顾性队列研究:本研究共调查了400名在内分泌诊所接受甲状腺切除术后确诊为TC的患者,并对他们进行了长达15年的随访。检查表包括患者的人口统计学特征、临床信息、治疗反应、复发和死亡:男性占 19.25%,女性占 80.75%。平均年龄为(41.005±15.58)岁。男性、65 岁以上、吸烟者、有 TC 家族史、未分化癌、多发病、III 期和 IV 期患者的死亡和复发风险明显更高(PPP=0.05)。每多活一年,复发概率就会增加 3%(P=0.009)。男性的复发几率是女性的 4.73 倍(PC结论:为了采取适当的治疗干预措施并进行细致的术后监测,考虑相关因素的预测影响至关重要。由于 TC 的发病率增加、诊断时年龄较小且总体预后良好,因此在早期诊断 TC 对医疗系统至关重要。
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来源期刊
Journal of research in health sciences
Journal of research in health sciences PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
2.30
自引率
13.30%
发文量
7
期刊介绍: The Journal of Research in Health Sciences (JRHS) is the official journal of the School of Public Health; Hamadan University of Medical Sciences, which is published quarterly. Since 2017, JRHS is published electronically. JRHS is a peer-reviewed, scientific publication which is produced quarterly and is a multidisciplinary journal in the field of public health, publishing contributions from Epidemiology, Biostatistics, Public Health, Occupational Health, Environmental Health, Health Education, and Preventive and Social Medicine. We do not publish clinical trials, nursing studies, animal studies, qualitative studies, nutritional studies, health insurance, and hospital management. In addition, we do not publish the results of laboratory and chemical studies in the field of ergonomics, occupational health, and environmental health
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