Recommendations for defining disturbed flow as laminar, transitional, or turbulent in assays of hemostasis and thrombosis: communication from the ISTH SSC Subcommittee on Biorheology.

IF 5.5 2区 医学 Q1 HEMATOLOGY Journal of Thrombosis and Haemostasis Pub Date : 2024-10-10 DOI:10.1016/j.jtha.2024.09.026
David L Bark, Eudorah F Vital, Cécile Oury, Wilbur A Lam, Elizabeth E Gardiner
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Abstract

Blood flow is vital to life, yet disturbed flow has been linked to atherosclerosis, thrombosis, and endothelial dysfunction. The commonly used hemodynamic descriptor "disturbed flow" found in disease and medical devices is not clearly defined in many studies. However, the specific flow regime-laminar, transitional, or turbulent-can have very different effects on hemostasis, thrombosis, and vascular health. Therefore, it remains important to clinically identify turbulence in cardiovascular flow and to have available assays that can be used to study effects of turbulence. The objective of the current communication was to 1) provide clarity and guidance for how to clinically identify turbulence, 2) define standard measures of turbulence that can allow the recreation of flow conditions in a benchtop assay, and 3) review how cells and proteins in the blood can be impacted by turbulence based on current literature.

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关于在止血和血栓形成试验中将扰动流定义为层流、过渡流或湍流的建议:来自 ISTH SSC 生物流变学小组委员会的通报。
血流对生命至关重要,但血流紊乱与动脉粥样硬化、血栓形成和内皮功能障碍有关。疾病和医疗设备中常用的血流动力学描述词 "紊乱血流 "在许多研究中都没有明确定义。然而,具体的流动机制:层流、过渡流或湍流,对止血、血栓形成和血管健康的影响却截然不同。因此,在临床上识别心血管流动中的湍流并提供可用于研究湍流影响的检测方法仍然非常重要。本次交流的目的是:1)为如何在临床上识别湍流提供清晰的指导;2)定义湍流的标准测量方法,以便在台式化验中再现流动条件;3)根据现有文献回顾血液中的细胞和蛋白质如何受到湍流的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis 医学-外周血管病
CiteScore
24.30
自引率
3.80%
发文量
321
审稿时长
1 months
期刊介绍: The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.
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