Protective effect of the branched short-chain fatty acid isobutyrate on intestinal damage in weaned piglets through intestinal microbiota remodeling.

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of the Science of Food and Agriculture Pub Date : 2024-10-16 DOI:10.1002/jsfa.13930

Xiuyu Fang, Zhengyi Wang, Qinrui Chen, Yongqing Du, Haowen Sun, Haiyang Liu, Ye Feng, Zhongyu Li, Teng Teng, Baoming Shi

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Abstract

Background: Postweaning intestinal damage in piglets is a challenging issue in the livestock industry. Short-chain fatty acids (SCFAs) are important metabolic products of the gut microbiota and are widely recognized for their role in maintaining normal colonic function and regulating the intestinal immune system. However, the effects of branched short-chain fatty acid (BSCFA) isobutyrate on intestinal health remain largely unknown. This study aims to explore the potential of isobutyrate for alleviating postweaning intestinal damage.

Results: This study indicates that isobutyrate can alleviate diarrhea in weaned piglets, enhance their growth performance, and optimize the gut microbiota. This is mainly achieved through increasing the relative abundance of probiotic bacteria such as Lactobacillus, Megasphaera, and Prevotellaceae_UCG-003, while concurrently reducing the relative abundance of potentially harmful bacteria such as Clostridium_sensu_stricto-1 and Escherichia-Shigella. It promotes the production of SCFAs, including acetate, isobutyrate, and butyrate. Furthermore, it activates G-protein-coupled receptors (GPR43/109A), inhibits the TLR4/MyD88 signaling pathway, strengthens the intestinal barrier function, and regulates the expression of related cytokines.

Conclusion: In summary, exogenous isobutyrate can be considered a promising feed additive for improving the intestinal microbiota and regulating intestinal health in piglets. © 2024 Society of Chemical Industry.

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支链短链脂肪酸异丁酸盐通过肠道微生物群重塑对断奶仔猪肠道损伤的保护作用

背景：仔猪断奶后的肠道损伤是畜牧业面临的一个挑战性问题。短链脂肪酸（SCFA）是肠道微生物群的重要代谢产物，在维持结肠正常功能和调节肠道免疫系统方面的作用已得到广泛认可。然而，支链短链脂肪酸（BSCFA）异丁酸盐对肠道健康的影响在很大程度上仍然未知。本研究旨在探索异丁酸盐减轻断奶后肠道损伤的潜力：本研究表明，异丁酸盐可减轻断奶仔猪的腹泻，提高其生长性能，并优化肠道微生物群。这主要是通过增加益生菌（如乳酸杆菌、甲球菌和普氏菌_UCG-003）的相对丰度来实现的，同时降低潜在有害菌（如梭菌_sensu_stricto-1 和志贺氏杆菌）的相对丰度。它能促进 SCFAs（包括乙酸盐、异丁酸盐和丁酸盐）的产生。此外，它还能激活 G 蛋白偶联受体（GPR43/109A），抑制 TLR4/MyD88 信号通路，增强肠道屏障功能，并调节相关细胞因子的表达：总之，外源性异丁酸盐可被视为一种很有前景的饲料添加剂，用于改善仔猪肠道微生物群和调节肠道健康。© 2024 化学工业协会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.