Association of Liver Disease and Chronic Pruritus: A Case–Control Study

IF 5.2 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Liver International Pub Date : 2024-10-18 DOI:10.1111/liv.16126

Luis F. Andrade, Zaim Haq, Parsa Abdi, Michael J. Diaz, Cynthia Levy, Gil Yosipovitch

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Abstract

Background & Methods

Through the identification of 22 803 cases of chronic pruritus, with a control group comprising 91 212 participants from a national database, we performed a comparative analysis revealing that patients with chronic pruritus had a significantly higher prevalence of liver disease compared to controls.

Results

Upon reverse analysis, we similarly found patients with liver disease had a significantly higher prevalence of chronic pruritus. Subsequent multivariate logistic regression highlighted increased odds for several liver diseases in the pruritus cohort, including metabolic dysfunction-associated steatotic liver disease (aOR 1.65, 95% CI 1.53–1.78) and alcohol-related liver disease (aOR 1.69, 95% CI 1.43–1.98). The increased odds were most pronounced for hepatitis B (aOR 2.01, 95% CI 1.67–2.42) and cholangitis + primary sclerosing cholangitis + primary biliary cholangitis (aOR 1.81, 95% CI 1.65–1.99).

Conclusion

Our results reveal a strong correlation between pruritus in hepatic pathologies different than commonly reported cholestatic diseases.

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肝脏疾病与慢性瘙痒症的关系：病例对照研究

背景与方法我们从国家数据库中找出了22 803例慢性瘙痒症患者，并与由91 212名参与者组成的对照组进行了对比分析，结果发现，与对照组相比，慢性瘙痒症患者的肝病患病率明显更高：经过反向分析，我们同样发现肝病患者的慢性瘙痒症发病率明显高于对照组。随后的多变量逻辑回归显示，瘙痒症队列中几种肝病的患病几率增加，包括代谢功能障碍相关性脂肪肝（aOR 1.65，95% CI 1.53-1.78）和酒精相关性肝病（aOR 1.69，95% CI 1.43-1.98）。乙型肝炎（aOR 2.01，95% CI 1.67-2.42）和胆管炎+原发性硬化性胆管炎+原发性胆汁性胆管炎（aOR 1.81，95% CI 1.65-1.99）的几率增加最为明显：我们的研究结果表明，与常见的胆汁淤积性疾病不同，肝脏病变与瘙痒之间存在密切的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Liver International 医学-胃肠肝病学

CiteScore

13.90

自引率

4.50%

发文量

348

审稿时长

2 months

期刊介绍： Liver International promotes all aspects of the science of hepatology from basic research to applied clinical studies. Providing an international forum for the publication of high-quality original research in hepatology, it is an essential resource for everyone working on normal and abnormal structure and function in the liver and its constituent cells, including clinicians and basic scientists involved in the multi-disciplinary field of hepatology. The journal welcomes articles from all fields of hepatology, which may be published as original articles, brief definitive reports, reviews, mini-reviews, images in hepatology and letters to the Editor.