Association of ultra-processed food consumption with cardiovascular risk factors among patients with type-2 diabetes mellitus.

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Nutrition & Diabetes Pub Date : 2024-10-22 DOI:10.1038/s41387-024-00337-8
Mohammad Heidari Seyedmahalleh, Ensieh Nasli-Esfahani, Mobina Zeinalabedini, Leila Azadbakht
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Abstract

Background: Ultra-processed foods mainly have high energy content and density and low nutrients. Unhealthy lifestyles mainly develop cardiovascular diseases and, as a result, unhealthy food patterns.

Objective: This study aimed to investigate the relationship between the consumption of ultra-processed foods (UPFs) and the risk of novel cardiovascular disease (CVDs) in type-2 diabetes mellitus patients (T2DM).

Method: This is a cross-sectional study that was conducted on 490 type-2 diabetes mellitus patients. A validated 168-item food frequency questionnaire evaluated food intake. Ultra-processed foods were assessed according to NOVA classification. Cardiovascular risk factors such as Castelli risk index 1 and 2 (CRI-I and II), atherogenic index of plasma (AIP), lipid accumulation product (LAP), and cholesterol index (CI) were assessed by traditional CVD risk factors. The anthropometric indices predicting CVD, such as a body shape index (ABSI), body roundness index (BRI), and abdominal volume index (AVI), were assessed.

Results: Each 20-gram increase in UPF consumption was associated with a significant elevation in serum level of TC [B (SE): 1.214 (0.537); 95% CI: 0.159-2.269] and lower HDL serum concentration [B (SE): -0.371 (0.155); 95% CI: -0.675 to -0.067]. The crude model for CRI 1 [B (SE): 0.032 (0.012); 95% CI: 0.009-0.056], CRI 2 [B (SE): 0.022 (0.009); 95% CI: 0.004-0.040], and AIP [B (SE): 0.006 (0.003); 95% CI: 0.000-0.012] showed significant adverse effects.

Conclusions: Our study showed that higher consumption of UPFs is associated with higher chances of developing cardiovascular diseases in T2DM patients.

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2 型糖尿病患者食用超加工食品与心血管风险因素的关系。
背景:超加工食品主要具有高能量、高密度和低营养的特点。不健康的生活方式主要会引发心血管疾病,从而导致不健康的饮食模式:本研究旨在调查 2 型糖尿病患者(T2DM)食用超加工食品(UPFs)与新型心血管疾病(CVDs)风险之间的关系:这是一项横断面研究,对象是490名2型糖尿病患者。经过验证的 168 项食物频率问卷评估了食物摄入量。根据诺瓦分类法评估了超加工食品。心血管风险因素,如卡斯泰利风险指数 1 和 2(CRI-I 和 II)、血浆致动脉粥样硬化指数(AIP)、脂质累积产物(LAP)和胆固醇指数(CI),则通过传统的心血管疾病风险因素进行评估。还评估了预测心血管疾病的人体测量指数,如体形指数(ABSI)、体圆指数(BRI)和腹部体积指数(AVI):UPF消耗量每增加20克,血清总胆固醇水平就会显著升高[B(SE):1.214(0.537);95% CI:0.159-2.269],高密度脂蛋白血清浓度也会降低[B(SE):-0.371(0.155);95% CI:-0.675--0.067]。CRI 1 [B (SE):0.032 (0.012);95% CI:0.009-0.056]、CRI 2 [B (SE):0.022 (0.009);95% CI:0.004-0.040]和 AIP [B (SE):0.006 (0.003);95% CI:0.000-0.012]的粗略模型显示出显著的不利影响:我们的研究表明,T2DM 患者摄入较多的 UPFs 与较高的心血管疾病发病几率有关。
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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
期刊最新文献
Late eating is associated with poor glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 diabetes. Association of ultra-processed food consumption with cardiovascular risk factors among patients with type-2 diabetes mellitus. Gestational diabetes exacerbates intrauterine microbial exposure induced intestinal microbiota change in offspring contributing to increased immune response. Soluble receptors for advanced glycation endproducts are predictors of insulin sensitivity and affected by weight loss. Impaired brain glucose metabolism in glucagon-like peptide-1 receptor knockout mice.
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