Comparison of Syn T2-FLAIR and Syn DIR with conventional T2-FLAIR in displaying white matter hyperintensities in migraine patients.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-10-21 DOI:10.1007/s00234-024-03477-x

Zhen-Zhen Liu, Hai-Yang Yu, Yuan-Hui Li, Zhi-Cheng Zhang, Bin-Liang Zhao, Jie Zhang, Ruo-Mi Guo

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Abstract

Objective: Young migraine patients often present with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI). This study aimed to analyze whether synthetic (Syn) T2-FLAIR and Syn double inversion recovery (DIR) can reveal WMHs more clearly and sensitively than conventional T2-FLAIR.

Materials and methods: Conventional MRI and Syn MRI data from 50 young migraine patients were analyzed prospectively. WMHs in each anatomical region (periventricular, deep white matter, and juxtacortical) were recorded separately. The differences in the clarity of lesion boundaries and the number of lesions displayed in the three sequences in the same anatomical region were analyzed.

Results: A total of 80 (periventricular area, 15; deep white matter, 31; juxtacortical area, 34), 163 (17, 50, 96), and 134 (18, 42, 74) lesions were observed with conventional T2-FLAIR, Syn T2-FLAIR, and Syn DIR, respectively. Syn T2-FLAIR and Syn DIR can show lesions more clearly than conventional T2-FLAIR (all P < 0.001). There was no significant difference in the number of lesions observed in the periventricular white matter among the three sequences (P = 0.159, 0.083, 0.322). Syn T2-FLAIR and Syn DIR can detect more lesions in the deep white matter than conventional T2-FLAIR (P < 0.001, P = 0.006). Syn T2-FLAIR revealed more lesions in the juxtacortical white matter than Syn DIR and conventional T2-FLAIR imaging (all P < 0.001), and conventional T2-FLAIR revealed the fewest lesions (P < 0.001).

Conclusion: Syn T2-FLAIR and Syn DIR sequences can clearly and sensitively detect WMHs, especially in deep and juxtacortical white matter areas.

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Syn T2-FLAIR 和 Syn DIR 与传统 T2-FLAIR 在显示偏头痛患者白质高密度方面的比较。

目的：年轻的偏头痛患者在磁共振成像（MRI）上经常出现白质高密度（WMH）。本研究旨在分析合成（Syn）T2-FLAIR 和 Syn 双反转恢复（DIR）是否能比传统 T2-FLAIR 更清晰、更灵敏地显示 WMH：对 50 名年轻偏头痛患者的常规 MRI 和 Syn MRI 数据进行了前瞻性分析。分别记录了每个解剖区域（脑室周围、深部白质和并皮质）的 WMHs。分析了同一解剖区域中三种序列显示的病变边界清晰度和病变数量的差异：结果：传统 T2-FLAIR、Syn T2-FLAIR 和 Syn DIR 分别观察到 80 个（室周区，15 个；深部白质，31 个；皮质并区，34 个）、163 个（17 个，50 个，96 个）和 134 个（18 个，42 个，74 个）病灶。与传统 T2-FLAIR 相比，Syn T2-FLAIR 和 Syn DIR 能更清晰地显示病变（均为 P 结论：Syn T2-FLAIR 和 Syn DIR 能更清晰地显示病变（均为 P 结论）：Syn T2-FLAIR 和 Syn DIR 序列能清晰、灵敏地检测出 WMHs，尤其是在深部和并皮质白质区域。

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