metsDB: a knowledgebase of cancer metastasis at bulk, single-cell and spatial levels.

IF 16.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nucleic Acids Research Pub Date : 2025-01-06 DOI:10.1093/nar/gkae916

Sijia Wu, Jiajin Zhang, Yanfei Wang, Xinyu Qin, Zhaocan Zhang, Zhennan Lu, Pora Kim, Xiaobo Zhou, Liyu Huang

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Abstract

Cancer metastasis, the process by which tumour cells migrate and colonize distant organs from a primary site, is responsible for the majority of cancer-related deaths. Understanding the cellular and molecular mechanisms underlying this complex process is essential for developing effective metastasis prevention and therapy strategies. To this end, we systematically analysed 1786 bulk tissue samples from 13 cancer types, 988 463 single cells from 17 cancer types, and 40 252 spots from 45 spatial slides across 10 cancer types. The results of these analyses are compiled in the metsDB database, accessible at https://relab.xidian.edu.cn/metsDB/. This database provides insights into alterations in cell constitutions, cell relationships, biological pathways, molecular biomarkers, and drug responses during cancer metastasis at bulk, single-cell, and spatial levels. Users can perform cell or gene searches to obtain multi-view and multi-scale metastasis-related data. This comprehensive resource is invaluable for understanding the metastasis process and for designing molecular therapies.

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metsDB：大体、单细胞和空间层面的癌症转移知识库。

癌症转移是肿瘤细胞从原发部位向远处器官迁移和定植的过程，是造成大多数癌症相关死亡的原因。了解这一复杂过程的细胞和分子机制对于制定有效的转移预防和治疗策略至关重要。为此，我们系统分析了来自 13 种癌症类型的 1786 份大块组织样本、来自 17 种癌症类型的 988 463 个单细胞以及来自 10 种癌症类型的 45 张空间切片中的 40 252 个点。这些分析结果汇编成 metsDB 数据库，可在 https://relab.xidian.edu.cn/metsDB/ 上访问。该数据库提供了对癌症转移过程中细胞结构、细胞关系、生物通路、分子生物标记物和药物反应在体细胞、单细胞和空间水平上的改变的深入了解。用户可以进行细胞或基因搜索，获取多视角和多尺度的转移相关数据。这一全面的资源对于了解转移过程和设计分子疗法非常宝贵。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nucleic Acids Research 生物-生化与分子生物学

CiteScore

27.10

自引率

4.70%

发文量

1057

审稿时长

2 months

期刊介绍： Nucleic Acids Research (NAR) is a scientific journal that publishes research on various aspects of nucleic acids and proteins involved in nucleic acid metabolism and interactions. It covers areas such as chemistry and synthetic biology, computational biology, gene regulation, chromatin and epigenetics, genome integrity, repair and replication, genomics, molecular biology, nucleic acid enzymes, RNA, and structural biology. The journal also includes a Survey and Summary section for brief reviews. Additionally, each year, the first issue is dedicated to biological databases, and an issue in July focuses on web-based software resources for the biological community. Nucleic Acids Research is indexed by several services including Abstracts on Hygiene and Communicable Diseases, Animal Breeding Abstracts, Agricultural Engineering Abstracts, Agbiotech News and Information, BIOSIS Previews, CAB Abstracts, and EMBASE.