Intraocular Pressure Fluctuation as Assessed by Water Drinking Test Following iStent inject Implantation in Open Angle Glaucoma Patients.

IF 2 4区 医学 Q2 OPHTHALMOLOGY Ophthalmic Research Pub Date : 2024-10-18 DOI:10.1159/000542081
Phong Yue Khoo, Chenshen Lam, Seng Fai Tang, Shamira Perera, Norshamsiah Md Din
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Abstract

Introduction This study investigated the intraocular pressure (IOP) fluctuation as assessed by the water drinking test (WDT) in open-angle glaucoma (OAG) patients after combined cataract surgery with iStent implantation. Methods This was a prospective non-randomized comparative study. Eyes with OAG and cataracts that were planned for either combined phacoemulsification and iStent implantation (iStent+CS) or phacoemulsification alone (CS) were recruited. The iStent inject (Model G2-M-IS) or iStent injectW (Model G2-W) trabecular micro-bypass stent (Glaukos Corporation, San Clemente, CA, USA) was implanted in the iStent+CS group. Water drinking test (WDT) was performed before and 3 months after surgery. WDT-IOP parameters including peak IOP, IOP fluctuation, and area under curve (AUC) were compared between the two groups. Results There were 20 eyes in the iStent+CS group and 16 eyes in the CS group. Both groups had similar pre-operative baseline IOP (15.6 ± 3.7 mmHg vs 15.8 ± 1.8 mmHg in the iStent+CS and CS group, respectively, p = 0.883). The iStent+CS group experienced greater numerical reduction in peak IOP (2.6 ± 1.9 mmHg vs 1.9 ± 2.4 mmHg; p = 0.355), IOP fluctuation (1.7 ± 2.2 mmHg vs 0.8 ± 2.5 mmHg; p = 0.289), and AUC (54.8 ± 103.6 mmHg x minute vs 25.3 ± 79.0 mmHg x minute; p = 0.355) than the CS group. There was more reduction in the number of anti-glaucoma medications in the iStent+CS group (1.4 ± 1.2) than the CS group (0.3 ± 0.9; p = 0.005). Conclusion Both combined phacoemulsification with iStent inject implantation and phacoemulsification alone reduced peak IOP, IOP fluctuation, and AUC, and none of these parameters showed statistically significant difference. Greater reduction in anti-glaucoma medications was seen in the combined group.

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开角型青光眼患者植入 iStent 注射器后通过饮水测试评估眼压波动。
引言 本研究通过饮水试验(WDT)评估开角型青光眼(OAG)患者在联合白内障手术和 iStent 植入术后的眼压波动情况。方法 这是一项前瞻性非随机对比研究。研究人员招募了计划接受联合乳化手术和 iStent 植入术(iStent+CS)或单纯乳化手术(CS)的 OAG 和白内障患者。iStent+CS 组植入 iStent inject(G2-M-IS 型)或 iStent injectW(G2-W 型)小梁微旁路支架(Glaukos Corporation,San Clemente,CA,USA)。术前和术后 3 个月进行饮水测试(WDT)。比较两组的饮水试验-眼压参数,包括峰值眼压、眼压波动和曲线下面积(AUC)。结果 iStent+CS 组有 20 只眼,CS 组有 16 只眼。两组的术前基线眼压相似(iStent+CS 组和 CS 组分别为 15.6 ± 3.7 mmHg vs 15.8 ± 1.8 mmHg,p = 0.883)。与 CS 组相比,iStent+CS 组的峰值 IOP(2.6 ± 1.9 mmHg vs 1.9 ± 2.4 mmHg;p = 0.355)、IOP 波动(1.7 ± 2.2 mmHg vs 0.8 ± 2.5 mmHg;p = 0.289)和 AUC(54.8 ± 103.6 mmHg x 分钟 vs 25.3 ± 79.0 mmHg x 分钟;p = 0.355)的数值降低幅度更大。iStent+CS组(1.4 ± 1.2)比CS组(0.3 ± 0.9;p = 0.005)减少了更多抗青光眼药物。结论 联合超声乳化加 iStent 注射植入术和单纯超声乳化术都能降低峰值眼压、眼压波动和 AUC,而且这些参数在统计学上都没有显著差异。联合组减少的抗青光眼药物更多。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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