Changes in Skin Barrier Function in Neonates: Daily Variation and Impact of Bathing.

IF 1.2 4区医学 Q3 DERMATOLOGY Pediatric Dermatology Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI:10.1111/pde.15772

Fumi Tanaka, Chiemi Hayashi, Mayumi Iida, Kimika Shinya, Masaki Futamura

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Abstract

Background: The skin barrier function is an important predictor of neonatal barrier defects. This study aimed to investigate the daily changes in skin barrier function and the impact of bathing on skin barrier function in neonates.

Methods: We assessed the transepidermal water loss (TEWL) and stratum corneum hydration (SCH) on the forehead, cheek, volar forearm, and chest from days 2 to 7 and at 1 month after birth. Additionally, we measured the values after bathing and compared them with the pre-bathing values.

Results: Sixty-six neonates were involved in the assessment, and each value at the four sites showed significant correlations. TEWL remained stable between days 2 and 7, but SCH significantly increased at most sites. Both significantly increased by 1.5-2 times in 1 month. After bathing, TEWL increased by more than 20% but decreased again after 3 h.

Conclusions: TEWL did not change significantly with age during the first week of life. To minimize the effects of bathing, TEWL should be measured at least 3 h after bathing.

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新生儿皮肤屏障功能的变化：每日变化和沐浴的影响

背景：皮肤屏障功能是预测新生儿屏障缺陷的重要指标。本研究旨在调查新生儿皮肤屏障功能的日常变化以及洗澡对皮肤屏障功能的影响：我们评估了新生儿出生后第 2 到 7 天和 1 个月时前额、脸颊、前臂和胸部的经表皮失水率 (TEWL) 和角质层水合率 (SCH)。此外，我们还测量了洗澡后的数值，并与洗澡前的数值进行了比较：结果：66 名新生儿参与了评估，四个部位的每个数值都显示出显著的相关性。在第 2 天和第 7 天之间，TEWL 保持稳定，但 SCH 在大多数部位显著增加。在 1 个月内，两者都明显增加了 1.5-2 倍。沐浴后，TEWL 增加了 20% 以上，但 3 小时后又下降了：结论：在出生后的第一周，TEWL并没有随着年龄的增长而发生明显变化。为尽量减少洗澡的影响，应在洗澡后至少 3 小时测量 TEWL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

6.70%

发文量

269

审稿时长

1 months

期刊介绍： Pediatric Dermatology answers the need for new ideas and strategies for today''s pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances. As important progress is made in any area involving infants and children, Pediatric Dermatology is there to publish the findings.