Contemporary surgical management of osteosarcoma and Ewing sarcoma.

IF 2.4 3区 医学 Q2 HEMATOLOGY Pediatric Blood & Cancer Pub Date : 2024-10-15 DOI:10.1002/pbc.31374
Alexandra K Callan, John H Alexander, Nicole I Montgomery, Antoinette W Lindberg, Thomas J Scharschmidt, Odion Binitie
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Abstract

The incidence of malignant bone tumors has remained relatively stable over the past two decades between 8% and 9% per 1,000,000 in North America. Multidisciplinary treatment is paramount for optimal care combining surgical resection, chemotherapy, and rehabilitation. Surgical treatment aims for a negative margin resection of the sarcoma with a personalized reconstruction plan. Limb salvage surgery (LSS) is possible in the majority of cases; however, amputation (including rotationplasty) may be required or preferred. Reconstruction can be achieved utilizing endoprostheses, allograft, autograft, or a combination of these techniques. Emerging technologies such as 3D printing of implants and cutting guides, and intraoperative navigation have helped to improve options for LSS.

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骨肉瘤和尤文肉瘤的当代外科治疗。
在过去二十年里,北美地区恶性骨肿瘤的发病率一直保持在每 100 万人 8%至 9% 之间,相对稳定。多学科治疗是结合手术切除、化疗和康复治疗的最佳治疗方法。手术治疗的目的是阴性边缘切除肉瘤,并制定个性化的重建计划。大多数病例都可以进行肢体挽救手术(LSS),但可能需要或首选截肢(包括旋转成形术)。重建可采用内假体、同种异体移植、自体移植或这些技术的组合。植入物和切割导板的三维打印以及术中导航等新兴技术有助于改善 LSS 的治疗方案。
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来源期刊
Pediatric Blood & Cancer
Pediatric Blood & Cancer 医学-小儿科
CiteScore
4.90
自引率
9.40%
发文量
546
审稿时长
1.5 months
期刊介绍: Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.
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