The PINK1/Parkin signaling pathway-mediated mitophagy: a forgotten protagonist in myocardial ischemia/reperfusion injury

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY Pharmacological research Pub Date : 2024-10-15 DOI:10.1016/j.phrs.2024.107466

Xiaopeng Zhao , Zheng Wang , Lijie Wang , Tao Jiang , Dan Dong , Mingli Sun

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Abstract

Myocardial ischemia causes extensive damage, further exacerbated by reperfusion, a phenomenon called myocardial ischemia/reperfusion injury (MIRI). Nowadays, the pathological mechanisms of MIRI have received extensive attention. Oxidative stress, multiple programmed cell deaths, inflammation and others are all essential pathological mechanisms contributing to MIRI. Mitochondria are the energy supply centers of cells. Numerous studies have found that abnormal mitochondrial function is an essential "culprit" of MIRI, and mitophagy mediated by the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1)/Parkin signaling pathway is an integral part of maintaining mitochondrial function. Therefore, exploring the association between the PINK1/Parkin signaling pathway-mediated mitophagy and MIRI is crucial. This review will mainly summarize the crucial role of the PINK1/Parkin signaling pathway-mediated mitophagy in MIR-induced several pathological mechanisms and various potential interventions that affect the PINK1/Parkin signaling pathway-mediated mitophagy, thus ameliorating MIRI.

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PINK1/Parkin信号通路介导的有丝分裂：心肌缺血/再灌注损伤中被遗忘的主角。

心肌缺血会造成广泛的损伤，再灌注又会进一步加剧这种损伤，这种现象被称为心肌缺血再灌注损伤（MIRI）。如今，心肌缺血再灌注损伤的病理机制已受到广泛关注。氧化应激、多种程序性细胞死亡、炎症等都是导致 MIRI 的重要病理机制。线粒体是细胞的能量供应中心。大量研究发现，线粒体功能异常是导致 MIRI 的重要 "元凶"，而由磷酸酶和天丝同源物（PTEN）诱导激酶 1（PINK1）/Parkin 信号通路介导的线粒体吞噬作用是维持线粒体功能不可或缺的一部分。因此，探索 PINK1/Parkin 信号通路介导的有丝分裂与 MIRI 之间的关联至关重要。本综述将主要总结 PINK1/Parkin 信号通路介导的有丝分裂在 MIR 诱导的几种病理机制中的关键作用，以及影响 PINK1/Parkin 信号通路介导的有丝分裂从而改善 MIRI 的各种潜在干预措施。

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.