Respiratory sequelae after COVID-19 infection in Thai healthy children.

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Pulmonology Pub Date : 2024-10-16 DOI:10.1002/ppul.27329

Sirapoom Niamsanit, Wicharn Boonjindasup, Suchada Sritippayawan, Jitladda Deerojanawong, Nuanchan Prapphal, Chanthana Harnruthakorn, Jiratchaya Sophonphan, Watit Niyomkarn

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Abstract

Background and aims: The long-term respiratory sequelae of COVID-19 infection in children remain poorly understood and may differ across countries. This study aims to investigate the respiratory sequelae, including residual respiratory symptoms and pulmonary function in Thai children. The secondary aim is to identify factors associated with the respiratory sequelae.

Materials and methods: This is an observational study involving 56 healthy children, aged between 7 and 18 years, who were diagnosed with COVID-19 infection from July 2021 to February 2023. Clinical data relating to COVID-19 infection and persistent symptoms after the infection were assessed after the infection up to 6 months. Spirometry was performed to assess pulmonary function.

Results: Post-COVID-19 symptoms were identified in 14 patients (25%), with fatigue, cough, and dyspnea being common symptoms (28%-35%). A significant correlation was found between post COVID-19 symptoms and pneumonia (OR = 6.00, 95%CI [1.54,23.33], p = .01). Abnormal pulmonary function was identified in 10 patients (17.8%) with obstructive impairment being the most common. However, there was no significant association between clinical factors and pulmonary function impairment.

Conclusion: Prolonged respiratory symptoms and abnormal pulmonary function following COVID-19 infection are not uncommon in children. The post-COVID-19 symptoms are possibly associated with COVID-19 pneumonia.

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泰国健康儿童感染 COVID-19 后的呼吸道后遗症。

背景和目的：人们对儿童感染 COVID-19 后的长期呼吸道后遗症仍然知之甚少，而且不同国家的情况可能也不尽相同。本研究旨在调查泰国儿童的呼吸道后遗症，包括残余呼吸道症状和肺功能。次要目的是确定与呼吸系统后遗症相关的因素：这是一项观察性研究，涉及 2021 年 7 月至 2023 年 2 月期间确诊感染 COVID-19 的 56 名 7 至 18 岁健康儿童。在感染后的 6 个月内，对与 COVID-19 感染和感染后持续症状相关的临床数据进行了评估。进行肺活量测定以评估肺功能：14名患者（25%）出现了COVID-19感染后症状，其中疲劳、咳嗽和呼吸困难是常见症状（28%-35%）。COVID-19 后症状与肺炎之间存在明显相关性（OR = 6.00，95%CI [1.54,23.33]，p = .01）。有 10 名患者（17.8%）发现肺功能异常，其中最常见的是阻塞性肺功能损害。然而，临床因素与肺功能损害之间并无明显关联：结论：儿童感染 COVID-19 后出现长时间呼吸道症状和肺功能异常的情况并不少见。COVID-19感染后的症状可能与COVID-19肺炎有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.