Etiology, Recent Advances, and Clinical Trials Data for the Treatment of Angioedema: A Review.

IF 1.4 Q4 PHARMACOLOGY & PHARMACY Reviews on recent clinical trials Pub Date : 2024-10-11 DOI:10.2174/0115748871307432240930051749
Mukul Nishad, Sushma Verma, Ramish Maqsood, Rashmi Saxena Pal
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Abstract

Angioedema is a health issue that affects parts of the body like the upper pulmonary and gastric pathways and is identified by abrupt, nonpitting enlargement of the skin, mucous membranes, or both. The swelling usually lasts a few hours to 72 hours and may appear as non-puritic, subcutaneous, or submucosal organ edema. It is characterized by localized swelling brought on by the release of histamine. Itching is rare, and usual areas of appearance include the hands, feet, face, and genitalia, with periorbital swelling being the most often. The main objective of this review article is to study in brief the classifications, etiology, pathophysiology, and clinical trial data by describing the recent advancement in the treatment of angioedema. Various research articles obtained from different journals indexed under Scopus and SCI were used to prepare the review article and for illustrative work software such as Biorender and Microsoft Word was used. Histamine-- mediated angioedema, linked to allergic reactions, coexists with urticaria. Bradykinin-mediated angioedema, exemplified by hereditary angioedema and acquired forms, lacks urticaria. Idiopathic angioedema, with uncertain etiology. Imitated angioedema results from non-IgE-mediated reactions, often induced by medications. It is a complicated medical condition with a variety of causes and mechanisms. Over time, outcomes for patients have been greatly improved by a growing understanding of its etiology, pathophysiology, and available treatments. The field of medical treatment for this difficult problem is always changing, and this is partly due to clinical trials.

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治疗血管性水肿的病因、最新进展和临床试验数据:综述。
血管性水肿是一种影响上肺和胃通路等身体部位的健康问题,表现为皮肤、粘膜或两者突然出现非点状肿大。肿胀通常持续几小时到 72 小时,可能表现为非瘙痒性、皮下或粘膜下器官水肿。其特点是组胺释放引起局部肿胀。瘙痒很少见,通常出现的部位包括手、脚、脸和生殖器,其中眶周肿胀最为常见。这篇综述文章的主要目的是简要研究血管性水肿的分类、病因学、病理生理学和临床试验数据,介绍治疗血管性水肿的最新进展。在撰写这篇综述文章时,使用了从 Scopus 和 SCI 收录的不同期刊上获取的各种研究文章,并使用了 Biorender 和 Microsoft Word 等软件进行说明工作。组胺介导的血管性水肿与荨麻疹并存,与过敏反应有关。缓激肽介导的血管性水肿,以遗传性血管性水肿和获得性血管性水肿为例,不伴有荨麻疹。特发性血管性水肿,病因不明。仿制性血管性水肿由非 IgE 介导的反应引起,通常由药物诱发。这是一种复杂的病症,病因和发病机制多种多样。随着时间的推移,人们对其病因、病理生理学和现有治疗方法的了解不断加深,患者的治疗效果也得到了极大改善。针对这一棘手问题的医疗领域一直在不断变化,这部分归功于临床试验。
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来源期刊
Reviews on recent clinical trials
Reviews on recent clinical trials PHARMACOLOGY & PHARMACY-
CiteScore
3.10
自引率
5.30%
发文量
44
期刊介绍: Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development and therapeutics. The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.
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