Efficacy of pharmacological interventions for ADHD: protocol for an updated systematic review and dose-response network meta-analysis.

IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Systematic Reviews Pub Date : 2024-10-12 DOI:10.1186/s13643-024-02675-1
Mikail Nourredine, Lucie Jurek, Georgia Salanti, Andrea Cipriani, Fabien Subtil, Orestis Efthimiou, Tasnim Hamza, Samuele Cortese
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Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) affects approximately 5% of children globally, with symptoms often persisting into adulthood. While pharmacological interventions are commonly employed for management, understanding the optimal dosing for efficacy and tolerability remains crucial. This study aims to conduct a dose-response network meta-analysis to estimate the efficacy of pharmacological treatments across different doses, aiming to inform clinical decision-making and improve treatment outcomes.

Methods: This updated systematic review will include randomized controlled trials evaluating ADHD medication efficacy in children, adolescents, and adults. An updated search from a 2018 NMA will be conducted across multiple electronic databases with no language restrictions, using specific eligibility criteria focused on randomized controlled trials. The primary outcome will assess the severity of ADHD core symptoms, while secondary outcomes will consider treatment tolerability. A dose-response Bayesian hierarchical model will be used to estimate dose-response curves for each medication, identifying optimal dosing strategies.

Discussion: With this dose-response network meta-analysis, we aim to better understand the dose-response relationship of pharmacological treatment in ADHD, which could help clinician to the identification of optimal doses.

Systematic review registration: OSF https://doi.org/10.17605/OSF.IO/3MY4A .

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药物干预多动症的疗效:最新系统综述和剂量反应网络荟萃分析方案。
背景:全球约有 5% 的儿童患有注意力缺陷/多动症 (ADHD),症状往往持续到成年。虽然药物干预是治疗的常用方法,但了解疗效和耐受性的最佳剂量仍然至关重要。本研究旨在进行剂量-反应网络荟萃分析,以估算不同剂量药物治疗的疗效,从而为临床决策提供依据并改善治疗效果:这项更新的系统综述将包括评估儿童、青少年和成人多动症药物疗效的随机对照试验。将在多个电子数据库中对 2018 年的 NMA 进行更新检索,没有语言限制,采用特定的资格标准,重点关注随机对照试验。主要结果将评估多动症核心症状的严重程度,次要结果将考虑治疗耐受性。将使用剂量反应贝叶斯分层模型来估计每种药物的剂量反应曲线,从而确定最佳剂量策略:通过这项剂量-反应网络荟萃分析,我们旨在更好地了解多动症药物治疗的剂量-反应关系,从而帮助临床医生确定最佳剂量:OSF https://doi.org/10.17605/OSF.IO/3MY4A 。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Systematic Reviews
Systematic Reviews Medicine-Medicine (miscellaneous)
CiteScore
8.30
自引率
0.00%
发文量
241
审稿时长
11 weeks
期刊介绍: Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modelling. At this time Systematic Reviews does not accept reviews of in vitro studies. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.
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