[Possibilities of post-processing of multislice computed tomography results in non-invasive diagnosis of pancreatic fibrosis].

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Terapevticheskii Arkhiv Pub Date : 2024-09-14 DOI:10.26442/00403660.2024.08.202831

I E Khatkov, K A Lesko, E A Dubtsova, S G Khomeriki, N S Karnaukhov, L V Vinokurova, E I Shurygina, N V Makarenko, R E Izrailov, I V Savina, D A Salimgereeva, M A Kiriukova, D S Bordin

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Abstract

Aim: To evaluate the possibilities of post-processing of multidetector computed tomography (CT) results in the non-invasive diagnosis of pancreatic fibrosis (PF).

Materials and methods: The study included 165 patients aged 57.91±13.5 years who underwent preoperative CT during surgical treatment for chronic pancreatitis and pancreatic cancer from April 2022 to February 2024. The normalized contrast ratios of pancreatic tissue in the pancreatic (NCPP) and venous (NCVP) phases, as well as the contrast ratio (CR) were measured. Pathomorphological assessment of PF performed in tissues outside neoplasm or desmoplastic reaction by the Kloppel and Maillet scale.

Results: The values of post-processing CT results were compared in groups with different degrees of PF. Mean CR values were significantly higher (p=0.001) in patients with severe PF (CR 1.16±0.65 HU) than in patients with mild PF (CR 0.78±0.31 HU). CR value significant increase (p=0.03) was found in patients with signs of inflammatory changes in the pancreas tissue (CR 1.14±0.6 HU) than in those without them (CR 0.81±0.3 HU). There were no significant differences between the values of NCPP and NCVP, and the degree of PF.

Conclusion: The CR value increased in patients with severe degree of PF. There was a relationship between CR value increase and the radiological density of pancreatic tissue in non-contrast phase and presence of early signs of pancreatic inflammatory changes. Thus, there was a relationship between CT postprocessing results and morphological signs of PF, which can be used for pancreatic fibrosis non-invasive diagnosis and identification of additional signs of early chronic pancreatitis.

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[多层计算机断层扫描结果后处理在胰腺纤维化无创诊断中的可能性]。

目的：评估多载体计算机断层扫描（CT）结果后处理在无创诊断胰腺纤维化（PF）中的可能性：研究对象包括2022年4月至2024年2月期间在慢性胰腺炎和胰腺癌手术治疗期间接受术前CT检查的165例患者，年龄（57.91±13.5）岁。测量了胰腺组织在胰腺期（NCPP）和静脉期（NCVP）的归一化对比度以及对比度比值（CR）。通过 Kloppel 和 Maillet 量表对肿瘤或脱鳞反应以外的组织进行病理形态学评估：结果：比较了不同程度 PF 组的 CT 后处理结果值。重度 PF 患者的平均 CR 值（CR 1.16±0.65HU）明显高于轻度 PF 患者（CR 0.78±0.31HU）（P=0.001）。胰腺组织有炎症变化迹象的患者（CR 1.14±0.6HU）比无炎症变化迹象的患者（CR 0.81±0.3HU）的 CR 值明显增加（P=0.03）。NCPP和NCVP值与PF程度之间无明显差异：结论：重度 PF 患者的 CR 值升高。结论：重度 PF 患者的 CR 值升高，CR 值升高与非对比相胰腺组织的放射学密度和胰腺炎症变化的早期征兆存在一定关系。因此，CT 后处理结果与胰腺纤维化的形态学征象之间存在一定关系，可用于胰腺纤维化的无创诊断和早期慢性胰腺炎其他征象的识别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Terapevticheskii Arkhiv 医学-医学：内科

CiteScore

1.40

自引率

33.30%

发文量

171

审稿时长

3-8 weeks

期刊介绍： Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.