Potential toxic effects linked to taurine interactions with alkanolamines and diisopropylamine.

Discover Water Pub Date : 2024-01-01 Epub Date: 2024-10-18 DOI:10.1007/s43832-024-00146-1
Erica Pensini, Caitlyn Hsiung, Nour Kashlan
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引用次数: 0

Abstract

Diisopropylamine (DIPA), aminomethyl propanol (AMP), amino ethoxy ethanol (AEE), diethanolamine (DEA), ethanolamine (EA), pyridine (PYR) and methyl diethanolamine (MDEA) are used for carbon capture and to sweeten sour gas, and are found in groundwater. They are also used in cosmetic products. Taurine is abundant in the body, with key biological functions linked to its charged SO groups. Interactions between SO and amines have not been studied, but can strongly affect the biological function of taurine. Fourier transform infrared spectroscopy indicates SO…HN hydrogen bonding between taurine and DIPA, AMP, AEE, DEA, EA and MDEA. These interactions induce the formation of hydrophobic amine-taurine clusters, thus decreasing amine miscibility in water, as revealed by light scattering. This effect is most marked for DIPA, leading to turbid mixtures indicative of micron-sized droplets. PYR and taurine likely interact via S…N bonding. This study offers insights regarding potential mechanisms of amine toxicity to humans.

Graphical abstract:

Supplementary information: The online version contains supplementary material available at 10.1007/s43832-024-00146-1.

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牛磺酸与烷醇胺和二异丙基胺相互作用的潜在毒性效应。
二异丙基胺 (DIPA)、氨基甲基丙醇 (AMP)、氨基乙氧基乙醇 (AEE)、二乙醇胺 (DEA)、乙醇胺 (EA)、吡啶 (PYR) 和甲基二乙醇胺 (MDEA) 可用于碳捕获和酸性气体甜味剂,并存在于地下水中。它们还用于化妆品。牛磺酸在人体内含量丰富,其主要生物功能与其带电的 SO 基团有关。目前尚未对 SO 与胺之间的相互作用进行研究,但这种相互作用会对牛磺酸的生物功能产生重大影响。傅立叶变换红外光谱显示,牛磺酸与 DIPA、AMP、AEE、DEA、EA 和 MDEA 之间存在 SO...HN 氢键。光散射显示,这些相互作用导致形成疏水性胺-牛磺酸簇,从而降低了胺在水中的混溶性。这种效应在 DIPA 中最为明显,导致混合物浑浊,显示出微米大小的液滴。PYR和牛磺酸可能通过S...N键相互作用。这项研究为了解胺对人体毒性的潜在机制提供了启示:在线版本包含补充材料,可查阅 10.1007/s43832-024-00146-1。
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来源期刊
Discover Water
Discover Water water research-
自引率
0.00%
发文量
13
审稿时长
23 days
期刊介绍: Discover Water is part of the Discover journal series committed to providing a streamlined submission process, rapid review and publication, and a high level of author service at every stage. It is an open access, community-focussed journal publishing research from across all fields relevant to water research. Discover Water is a broad, open access journal publishing research from across all fields relevant to the science and technology of water research and management. Discover Water covers not only research on water as a resource, for example for drinking, agriculture and sanitation, but also the impact of society on water, such as the effect of human activities on water availability and pollution. As such it looks at the overall role of water at a global level, including physical, chemical, biological, and ecological processes, and social, policy, and public health implications. It is also intended that articles published in Discover Water may help to support and accelerate United Nations Sustainable Development Goal 6: ‘Clean water and sanitation’.
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