Utilization of apitherapy in allergic asthma: A systematic review of clinical and preclinical studies.

IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Tzu Chi Medical Journal Pub Date : 2024-04-30 eCollection Date: 2024-10-01 DOI:10.4103/tcmj.tcmj_233_23
Nicolas Daniel Widjanarko, Jonathan Christianto Subagya, Josephine Immanuel Maksi, Felicia Grizelda Suryatenggara, Sharon Claudia Ethelyn Sihole
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Abstract

Objectives: This systematic review aimed to summarize the benefit of apitherapy in human and animal models of asthma.

Materials and methods: The procedures in this review were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 protocol, where MEDLINE, ProQuest, and EBSCOhost databases were used to obtain eligible studies dating to 2023. Furthermore, the risk of bias was assessed using Risk of Bias Tool 2.0 (RoB-2) for randomized-control trials and Systematic Review Centre for Laboratory Animal Experimentation's RoB for animal studies.

Results: A total of 12 studies were included in the review based on the predetermined eligibility criteria, consisting of 4 human and 8 animal model reports. Among the four human studies, two had a low risk, while the other two had some concerns of bias. In the case of eight animal model of asthma, a total of three domains had a high risk of bias. Moreover, the anti-inflammatory properties of apitherapy were demonstrated by its capacity to inhibit NF-κB, nuclear factor of activated T cells, and IgE antibodies, leading to decreased production of tumor necrosis factor-α, interleukin-2 (IL-2), IL-6, and IL-8, and an increase in IL-10 levels. These beneficial effects were reported to be associated with improvements in clinical manifestations and lung function parameters in human subjects. The use of apitherapy was also related to the restoration of airway structure, and reduction of inflammatory cell infiltration, epithelial thickness, and mucus secretion in lung tissue of animal model of asthma.

Conclusion: Based on the results, apitherapy was effective in improving asthma symptoms and reducing inflammation in human and animal models of asthma.

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在过敏性哮喘中使用哮喘治疗法:临床和临床前研究的系统回顾。
目的:本系统综述旨在总结哮喘治疗对人类和动物模型的益处:本综述根据《2020年系统综述和荟萃分析首选报告项目》(Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 protocol)执行,使用MEDLINE、ProQuest和EBSCOhost数据库获取2023年前符合条件的研究。此外,随机对照试验采用偏倚风险工具 2.0(RoB-2)评估偏倚风险,动物研究采用实验室动物实验系统综述中心的 RoB 评估偏倚风险:根据预先确定的资格标准,共有 12 项研究被纳入审查范围,其中包括 4 项人体研究和 8 项动物模型报告。在 4 项人体研究中,有 2 项风险较低,而另外 2 项则存在一些偏倚问题。在 8 个哮喘动物模型中,共有 3 个领域存在高偏倚风险。此外,抗哮喘疗法的抗炎特性还体现在它能够抑制 NF-κB、活化 T 细胞核因子和 IgE 抗体,从而减少肿瘤坏死因子-α、白细胞介素-2(IL-2)、IL-6 和 IL-8 的产生,并提高 IL-10 的水平。据报道,这些有益效果与人体临床表现和肺功能参数的改善有关。哮喘动物模型肺组织中的炎症细胞浸润、上皮厚度和粘液分泌减少也与使用哮喘治疗法恢复气道结构有关:结论:根据研究结果,气道疗法能有效改善人类和动物哮喘模型的哮喘症状并减轻炎症反应。
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来源期刊
Tzu Chi Medical Journal
Tzu Chi Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.40
自引率
0.00%
发文量
44
审稿时长
13 weeks
期刊介绍: The Tzu Chi Medical Journal is the peer-reviewed publication of the Buddhist Compassion Relief Tzu Chi Foundation, and includes original research papers on clinical medicine and basic science, case reports, clinical pathological pages, and review articles.
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