Deficiency of vitamin D is associated with antenatal depression: A cross-sectional study.

Helena Garcia Dos Santos, Aline Longoni, Jéssica Puchalski Trettim, Isabela Thurow Lemes, Júlia de Castro Menchaca, Cainá Correa do Amaral, Mariana Bonati de Matos, Luciana de Avila Quevedo, Fernanda Nedel, Gabriele Ghisleni, Diogo Onofre Souza, Ricardo Tavares Pinheiro, Adriano Martimbianco de Assis
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Abstract

Objective: Approximately 6 to 13% of women suffer from antenatal depression (AD) around the world. AD can lead to several health problems for mother-baby. Vitamin D is a molecule that appears to have great preventive/therapeutic potential against neuropsychiatric disorders. The present study aimed to analyze the association between deficiency of vitamin D and AD in pregnant women in a city in the south of Brazil (Pelotas, RS). We hypothesize that pregnant women with a positive AD diagnosis have deficient levels of 25-hydroxyvitamin D (25(OH)D).

Methods: This cross-sectional study was conducted in a cohort study (CEP/UCPEL 47807915.4.0000.5339). From this cohort, 180 pregnant women at up to 24 weeks gestation were selected (130 non-depressed and 50 depressed), and the diagnosis of depression was made using the MINI-Plus. Blood was collected and stored for the later analysis of vitamin D (25(OH)D) by chemiluminescence method. The SPSS program was used for data analysis, and p<0.05 was considered statistically significant.

Results: In our study, we showed a significant association between Major Depressive Episode current in the antenatal period and vitamin D deficiency (OR: 0.9; CI 95%: 0.9;1.0, p=0.003).

Conclusion: Our results demonstrate that vitamin D deficiency may be involved in major depressive disorder in the antenatal period, in this way it advised a follow-up of vitamin D levels in the pregnancy-puerperal cycle to minimize mental health problems in women and prevent developmental deficits in children.

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维生素 D 缺乏与产前抑郁有关:一项横断面研究。
目的:全世界约有 6% 至 13% 的妇女患有产前抑郁症(AD)。产前抑郁症可导致母婴出现多种健康问题。维生素 D 是一种对神经精神疾病具有巨大预防/治疗潜力的分子。本研究旨在分析巴西南部城市佩洛塔斯(Pelotas,RS)孕妇缺乏维生素 D 与抑郁症之间的关系。我们假设,被确诊患有注意力缺失症的孕妇体内缺乏 25- 羟维生素 D (25(OH)D):这项横断面研究是在一项队列研究(CEP/UCPEL 47807915.4.0000.5339)中进行的。从该队列中挑选了 180 名妊娠 24 周以内的孕妇(130 名非抑郁症孕妇和 50 名抑郁症孕妇),并使用 MINI-Plus 诊断抑郁症。采集并储存的血液用于日后通过化学发光法分析维生素 D (25(OH)D)。使用 SPSS 程序进行数据分析,并得出 pResults:我们的研究表明,产前重度抑郁发作与维生素 D 缺乏之间存在显著关联(OR:0.9;CI 95%:0.9;1.0,P=0.003):我们的研究结果表明,维生素 D 缺乏可能与产前重度抑郁症有关,因此建议在妊娠-产褥期对维生素 D 水平进行随访,以尽量减少妇女的心理健康问题,并预防儿童发育缺陷。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
32
审稿时长
13 weeks
期刊介绍: Information not localized
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