Herong Wang, Kelly M Bakulski, Freida Blostein, Brittany R Porath, John Dou, César Higgins Tejera, Lindsay H Ryan, Erin B Ware
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引用次数: 0
Abstract
Major depressive disorder accelerates DNA methylation age, a biological aging marker. Subclinical depressive symptoms are common, but their link to DNA methylation aging in older adults remains unexplored. This study analyzed the cross-sectional relationship between depressive symptoms and accelerated DNA methylation aging, considering gender and race/ethnicity in U.S. adults aged over 50. We used data from 3,882 diverse participants in the 2016 Health and Retirement Study wave, measuring blood DNA methylation age against chronologic age for acceleration. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple linear regression evaluated the association between depressive symptoms and DNA methylation age acceleration, adjusting for sociodemographic factors, blood cell proportions, and health behaviors (physical activity, alcohol use, smoking, and chronic conditions). Gender and race/ethnicity modifications were also tested. Depressive symptoms, measured by continuous CES-D score, high depressive symptoms (CES-D ≥ 4), or any symptoms (CES-D ≥ 1), significantly correlated with increased GrimAge DNA methylation age acceleration (all p ≤ .001) in unadjusted and sociodemographic-adjusted models but were nonsignificant in fully adjusted models. No significant gender or race/ethnicity effect modifications were found in fully adjusted models. Health behaviors significantly influence DNA methylation age acceleration and depressive phenotypes, underscoring the need to understand their roles in assessing psychological factors related to DNA methylation age acceleration. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
重度抑郁症会加速生物衰老标志 DNA 甲基化的衰老。亚临床抑郁症状很常见，但它们与老年人 DNA 甲基化老化之间的联系仍未得到研究。本研究分析了美国 50 岁以上成年人中抑郁症状与 DNA 甲基化加速老化之间的横断面关系，同时考虑了性别和种族/民族因素。我们使用了 2016 年健康与退休研究（Health and Retirement Study）波中 3882 名不同参与者的数据，测量了血液 DNA 甲基化年龄与计时年龄的加速度。抑郁症状采用流行病学研究中心抑郁（CES-D）量表进行评估。多元线性回归评估了抑郁症状与 DNA 甲基化年龄加速之间的关联，并对社会人口因素、血细胞比例和健康行为（体育锻炼、饮酒、吸烟和慢性病）进行了调整。此外，还测试了性别和种族/人种修正情况。在未调整和社会人口因素调整模型中，以连续 CES-D 评分、高抑郁症状（CES-D ≥ 4）或任何症状（CES-D ≥ 1）衡量的抑郁症状与 GrimAge DNA 甲基化年龄加速度的增加显著相关（所有 p 均小于 .001），但在完全调整模型中不显著。在完全调整模型中，没有发现明显的性别或种族/人种效应修正。健康行为对DNA甲基化年龄加速和抑郁表型有重大影响，这说明在评估与DNA甲基化年龄加速有关的心理因素时，需要了解健康行为的作用。(PsycInfo Database Record (c) 2024 APA, 版权所有）。
期刊介绍：
Psychology and Aging publishes original articles on adult development and aging. Such original articles include reports of research that may be applied, biobehavioral, clinical, educational, experimental (laboratory, field, or naturalistic studies), methodological, or psychosocial. Although the emphasis is on original research investigations, occasional theoretical analyses of research issues, practical clinical problems, or policy may appear, as well as critical reviews of a content area in adult development and aging. Clinical case studies that have theoretical significance are also appropriate. Brief reports are acceptable with the author"s agreement not to submit a full report to another journal.
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