Implications of p53 protein upregulation in oral lichen planus: a systematic review and meta-analysis.

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Medicina Oral Patologia Oral Y Cirugia Bucal Pub Date : 2024-11-01 DOI:10.4317/medoral.26808

C Keim-Del Pino, P Ramos-García, L-A Pimenta-Barros, M-Á González-Moles

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Abstract

Background: This systematic review and meta-analysis qualitatively and quantitatively analyzes the current evidence on the implications of p53 upregulation in oral lichen planus (OLP) assessed by immunohistochemical techniques, in order to identify molecular mechanisms involved in the behavior of OLP as an oral potentially malignant disorder.

Material and methods: We searched MEDLINE/PubMed, Embase, Web of Science and Scopus for studies published before February-2024. We critically assessed the methodological quality of primary-level studies and performed meta-analyses.

Results: Twenty-four individual studies met the inclusion criteria, comprising 721 OLP samples, in which the expression of p53 was analyzed through immunohistochemistry. Most OLP displayed p53 protein upregulation (pooled proportion [PP]= 66.76%, 95%CI=54.84-77.76). Regarding the magnitude of association analysis, oral squamous cell carcinoma (OSCC) cases showed a significantly higher frequency according to p53 expression in comparison to OLP (OR=2.79, 95%CI=1.84-4.24; p<0.001); while, OLP exhibited a significantly higher frequency for p53 expression in comparison to healthy controls (OR=5.70, 95%CI=2.90-11.19; p<0.001).

Conclusions: In conclusion, the present study demonstrates the frequent p53 protein upregulation in patients with OLP, which is probably indicating an antitumor response in an epithelium whose cells are under cellular stress and at risk of cancer.

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p53 蛋白上调对口腔扁平苔藓的影响：系统综述和荟萃分析。

背景：本系统综述和荟萃分析通过免疫组化技术，定性和定量分析了目前有关口腔扁平苔藓（OLP）中p53上调影响的证据，以确定OLP作为一种口腔潜在恶性疾病的行为所涉及的分子机制：我们检索了 MEDLINE/PubMed、Embase、Web of Science 和 Scopus 中 2024 年 2 月之前发表的研究。我们严格评估了初级研究的方法学质量，并进行了荟萃分析：24项研究符合纳入标准，包括721个OLP样本，其中p53的表达通过免疫组化进行了分析。大多数OLP显示p53蛋白上调（汇总比例[PP]=66.76%，95%CI=54.84-77.76）。就关联分析的程度而言，与 OLP 相比，口腔鳞状细胞癌（OSCC）病例出现 p53 表达的频率明显更高（OR=2.79，95%CI=1.84-4.24；p 结论：总之，本研究表明，P53 蛋白在 OLP 患者中频繁上调，这可能表明上皮细胞处于细胞应激状态，有发生癌症的风险，从而产生抗肿瘤反应。

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来源期刊

Medicina Oral Patologia Oral Y Cirugia Bucal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology