Elevated circulating regenerating islet-derived protein 4 levels in patients with metabolic syndrome and related to its key components.

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine Pub Date : 2024-10-16 DOI:10.1007/s12020-024-04056-z
Tianjiao Shen, Yu Yang, Yerui Lai, Hongmin Zhang, Dongfang Liu, Cong Wang, Ling Li, Weiwei Xu, Ke Li, Shengbing Li, Mengliu Yang
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Abstract

Purpose: Regenerating islet-derived protein 4 (REG4) is a secretory protein that belongs to the C-type lectin superfamily. This study aims to explore the diagnostic value of REG4 as a potential biomarker for metabolic syndrome by analyzing the correlation between serum REG4 levels and metabolic syndrome.

Methods: Serum REG4 levels were measured using enzyme-linked immunosorbent assay (ELISA). Bioinformatics analysis was conducted to investigate REG4-related genes and metabolic signaling pathways.

Results: Serum REG4 levels were significantly elevated in MetS patients compared to healthy controls (439.7 vs. 422.6 ng/L, p < 0.01). In addition, circulating REG4 levels showed a positive correlation with AUGg, HbA1c, VAI, BMI, WHR, TG, TC, LDL-C, while being inversely correlated with HDL-C in the study population. Serum REG4 levels were positively correlated with MetS score. Multiple linear regression analysis identified HOMA-IR and LDL-C as independent factors affecting serum REG4 concentration. Interventional studies have shown that OGTT can significantly increase serum REG4 levels in healthy individuals, but significantly reduce REG4 levels in MetS patients. Bioinformatics analysis suggested that REG4 is linked to several metabolism-related genes and is enriched in various metabolism-related signaling pathways.

Conclusion: REG4 may serve as a valuable biomarker and potential treatment target for insulin resistance (IR) and MetS.

Clinical trial registration number: ChiCTR2000032878.

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代谢综合征患者循环再生胰岛源性蛋白 4 水平升高及其主要成分的相关性。
目的:再生胰岛衍生蛋白4(REG4)是一种分泌蛋白,属于C型凝集素超家族。本研究旨在通过分析血清 REG4 水平与代谢综合征之间的相关性,探讨 REG4 作为代谢综合征潜在生物标志物的诊断价值:方法:使用酶联免疫吸附试验(ELISA)测定血清REG4水平。结果:血清 REG4 水平显著升高:结果:与健康对照组相比,MetS 患者的血清 REG4 水平明显升高(439.7 vs. 422.6 ng/L,p 结论:REG4 可作为一种有价值的检测指标:REG4可作为胰岛素抵抗(IR)和MetS的重要生物标志物和潜在治疗靶点:临床试验注册号:ChiCTR2000032878。
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来源期刊
Endocrine
Endocrine ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
5.40%
发文量
295
审稿时长
1.5 months
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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