Advances in multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer starvation therapy.

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2024-10-14 DOI:10.1017/erm.2024.28
Jinghan Cai, Yan Xu, Fei Liao
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Abstract

Cancer remains a significant threat to human health today. Even though starvation therapy and other treatment methods have recently advanced to a new level of rapid development in tumour treatment, their limited therapeutic effectiveness and unexpected side effects prevent them from becoming the first option in clinical treatment. With rapid advancement in nanotechnology, the utilization of nanomaterials in therapeutics offers the potential to address the shortcomings in cancer treatment. Notably, multifunctional metal-organic framework (MOF) has been widely employed in cancer therapy due to their customizable shape, adjustable diameter, high porosity, diverse compositions, large specific surface area, high degree of functionalization and strong biocompatibility. This paper reviews the current progress and success of MOF-based multifunctional nanoplatforms for cancer starvation therapy, as well as the prospects and potential barriers for the application of MOF nanoplatforms in cancer starvation therapy.

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基于多功能金属有机框架(MOF)的癌症饥饿疗法纳米平台的研究进展。
癌症仍然是当今人类健康的重大威胁。尽管饥饿疗法和其他治疗方法近年来在肿瘤治疗方面迅速发展到一个新水平,但其有限的治疗效果和意想不到的副作用使其无法成为临床治疗的首选。随着纳米技术的快速发展,利用纳米材料进行治疗有望解决癌症治疗中的不足。其中,多功能金属有机框架(MOF)因其形状可定制、直径可调节、孔隙率高、成分多样、比表面积大、功能化程度高、生物相容性强等特点,已被广泛应用于癌症治疗。本文综述了目前基于 MOF 的多功能纳米平台在癌症饥饿疗法中的应用进展和成功案例,以及 MOF 纳米平台在癌症饥饿疗法中的应用前景和潜在障碍。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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