Thrombocytopenia in dengue infection: mechanisms and a potential application.

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2024-10-14 DOI:10.1017/erm.2024.18
Ahmad Suhail Khazali, Waqiyuddin Hilmi Hadrawi, Fatimah Ibrahim, Shatrah Othman, Nurshamimi Nor Rashid
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Abstract

Thrombocytopenia is a common symptom and one of the warning signs of dengue virus (DENV) infection. Platelet depletion is critical as it may lead to other severe dengue symptoms. Understanding the molecular events of this condition during dengue infection is challenging because of the multifaceted factors involved in DENV infection and the dynamics of the disease progression. Platelet levels depend on the balance between platelet production and platelet consumption or clearance. Megakaryopoiesis and thrombopoiesis, two interdependent processes in platelet production, are hampered during dengue infection. Conversely, platelet elimination via platelet activation, apoptosis and clearance processes are elevated. Together, these anomalies contribute to thrombocytopenia in dengue patients. Targeting the molecular events of dengue-mediated thrombocytopenia shows great potential but still requires further investigation. Nonetheless, the application of new knowledge in this field, such as immature platelet fraction analysis, may facilitate physicians in monitoring the progression of the disease.

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登革热感染中的血小板减少症:机制与潜在应用。
血小板减少是登革热病毒(DENV)感染的常见症状和预警信号之一。血小板耗竭至关重要,因为它可能导致其他严重的登革热症状。由于登革热病毒感染和疾病进展的动态过程涉及多方面因素,因此了解登革热感染期间这种情况的分子事件具有挑战性。血小板水平取决于血小板生成与血小板消耗或清除之间的平衡。在登革热感染期间,血小板生成的两个相互依存的过程--巨核细胞生成和血栓生成--受到阻碍。相反,通过血小板活化、凋亡和清除过程消除血小板的功能增强。这些异常情况共同导致登革热患者血小板减少。针对登革热介导的血小板减少症分子事件的研究显示出巨大的潜力,但仍需进一步研究。不过,应用这一领域的新知识(如未成熟血小板组分分析)可能有助于医生监测疾病的进展。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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