The Relationship between Early Exposure to General Anesthesia and Neurobehavioral Deficits.

IF 2.3 4区医学 Q2 DEVELOPMENTAL BIOLOGY Developmental Neuroscience Pub Date : 2024-10-14 DOI:10.1159/000542005

Jinnan Xu, Fan Wang, Yi Gao, Chuanyu Qi, Tiannan Chen, Jia Yan

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Abstract

Background: In contemporary medical practice, general anesthesia plays an essential role in pediatric surgical procedures. While modern anesthetic protocols have demonstrated safety and efficacy across various pathological conditions, concerns persist regarding the potential neurotoxic effects associated with early exposure to general anesthesia.

Summary: Current research primarily examines the neurocognitive developmental impacts, with limited focus on neurobehavioral developmental disorders. This review presents a comprehensive analysis of clinical trial results related to five critical neurobehavioral developmental disorders: fine motor disability, attention-deficit hyperactivity disorder, impulse control disorders, autism spectrum disorder, and developmental coordination disorder. Furthermore, this review synthesizes insights from basic research on the potential toxicological mechanisms of general anesthetic agents that could influence clinical neurobehavioral changes. These findings provide valuable guidance for the prudent and safe utilization of anesthetic agents in pediatric patients.

Key messages: This review explores the potential connections between general anesthesia and five neurobehavioral disorders, highlighting the importance of cautious anesthetic use in children in light of current research findings.

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早期接触全身麻醉与神经行为缺陷之间的关系。

在当代医疗实践中，全身麻醉在小儿外科手术中发挥着至关重要的作用。虽然现代麻醉方案在各种病理情况下都表现出了安全性和有效性，但人们仍然担心早期接触全身麻醉可能会对神经系统造成影响。目前的研究主要探讨了对神经认知发育的影响，而对神经行为发育障碍的关注有限。本综述全面分析了与以下五种关键神经行为发育障碍有关的临床试验结果：精细运动障碍、注意力缺陷多动障碍 (ADHD)、冲动控制障碍 (ICD)、自闭症谱系障碍 (ASD) 和发育协调障碍 (DCD)。此外，该综述还综合了基础研究对可能影响临床神经行为变化的全身麻醉剂潜在毒理机制的见解。这些发现为儿童患者谨慎安全地使用麻醉剂提供了宝贵的指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental Neuroscience 医学-发育生物学

CiteScore

4.00

自引率

3.40%

发文量

审稿时长

>12 weeks

期刊介绍： ''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.