Sporadic Creutzfeldt Jakob disease: Case series in Peru.

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Colombia Medica Pub Date : 2024-03-30 eCollection Date: 2024-01-01 DOI:10.25100/cm.v55i1.5821

Stefany Espinoza, Diego Canales, Cecilia Calderón, David Diaz, Elliot Barreto-Acevedo

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Abstract

Description of the cases: A series of 6 cases with a probable diagnosis of sporadic CJD, treated in a Peruvian national reference hospital, are presented.

Clinical findings: The relevant clinical signs were rapidly progressive dementia and myoclonus, followed by akinetic mutism and pyramidal signs.

Treatment and results: Of the cases presented, 80% were men, with an average age of presentation of 65 years and duration from diagnosis to death of 6.5 months. Laboratory tests, images (Brain Resonance) and protein dosage 14.3.3 were performed to support the clinical suspicion. There is no effective treatment at the moment for said pathology.

Clinical relevance: Creutzfeldt-Jakob disease (CJD) is a progressive, fatal, neurodegenerative disease of low prevalence and incidence. Great clinical suspicion and the exclusion of other etiologies are required. Currently there is no treatment for this entity and there is a high probability of death before one year.

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零星克雅氏病：秘鲁病例系列。

病例描述：该系列病例共 6 例，可能被诊断为散发性脊髓灰质炎，在秘鲁一家国家参考医院接受治疗：相关临床症状为快速进展性痴呆和肌阵挛，随后出现运动性缄默症和锥体体征：病例中 80% 为男性，平均发病年龄为 65 岁，从确诊到死亡的病程为 6.5 个月。为证实临床怀疑，进行了实验室检查、图像（脑共振）和蛋白质剂量 14.3.3。上述病理目前尚无有效的治疗方法：克雅氏病（CJD）是一种进行性、致命的神经退行性疾病，发病率低。临床上需要高度怀疑并排除其他病因。目前还没有治疗这种疾病的方法，患者很有可能在一年前死亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colombia Medica MEDICINE, GENERAL & INTERNAL-

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Colombia Médica is an international peer-reviewed medical journal that will consider any original contribution that advances or illuminates medical science or practice, or that educates to the journal''s’ readers.The journal is owned by a non-profit organization, Universidad del Valle, and serves the scientific community strictly following the International Committee of Medical Journal Editors (ICMJE) and the World Association of Medical Editors (WAME) recommendations of policies on publication ethics policies for medical journals. Colombia Médica publishes original research articles, viewpoints and reviews in all areas of medical science and clinical practice. However, Colombia Médica gives the highest priority to papers on general and internal medicine, public health and primary health care.