Comparison of single shot and multishot diffusion-weighted imaging in 5-T magnetic resonance imaging for brain disease diagnosis.

IF 2.9 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Quantitative Imaging in Medicine and Surgery Pub Date : 2024-10-01 Epub Date: 2024-09-26 DOI:10.21037/qims-24-118
Hao Chen, Runyu Tang, Xiaopeng Song, Ran Zong, Jie Liu, Chuyue Jin, Kexue Deng
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Abstract

Background: Diffusion-weighted imaging (DWI) with single-shot echo-planar imaging (ssEPI) is a valuable tool for detecting acute brain lesions but does suffer from image distortions. Multishot echo-planar imaging (msEPI) is a technique for reducing such distortions. This study aimed to compare the image quality and diagnostic efficacy of ssEPI- and msEPI-DWI at 5.0 T for brain disease detection.

Methods: This study retrospectively reviewed images of 107 consecutive patients with suspected brain diseases who underwent ssEPI- and msEPI-DWI at 5.0 T at the First Affiliated Hospital of University of Science and Technology of China from August 2023 to September 2023. Two radiologists independently graded image quality and measured the image distortion. Signal-to-noise ratio, contrast-to-noise ratio, and apparent diffusion coefficient (ADC) were calculated and compared between ssEPI- and msEPI-DWI. Image quality scores were compared using the Wilcoxon test and other continuous variables by the paired t-test. The diagnostic accuracy of ADC values in distinguishing lesions from normal-appearing tissues was measured with the area under the curve (AUC).

Results: Image quality evaluation and distortion analysis revealed that msEPI-DWI significantly outperformed ssEPI-DWI (two-sided P<0.001). No significant difference was observed in signal-to-noise ratio, contrast-to-noise ratio, or ADC values between msEPI- and ssEPI-DWI (two-sided P≥0.601). The ADC values of msEPI- and ssEPI-DWI showed strong correlations for both lesions (r=0.97) and contralateral normal tissues (r=0.91) (two-sided P<0.001). Compared to those of the contralateral white matter, ADC values of low-grade gliomas (LGGs) were significantly higher [ssEPI-DWI: 1,119.9±273.1 vs. 805.1±73.9; msEPI-DWI: 1,196.2±355.6 vs. 757.3±98.0 (unit: ×10-6 mm2/s)], while the ADC values of acute cerebral infarction (ACI) lesions were significantly lower [ssEPI-DWI: 603.9±273.2 vs. 888.9±212.0; msEPI-DWI: 538.0±281.2 vs. 905.0±188.9 (unit: ×10-6 mm2/s)] (two-sided P≤0.003). The AUCs for detecting LGGs were excellent for both ssEPI-DWI [AUC =0.934; 95% confidence interval (CI): 0.84-1.00] and msEPI-DWI (AUC =0.944; 95% CI: 0.86-1.00) (two-sided P<0.001; two-sided DeLong test: P=0.833).

Conclusions: As compared to ssEPI-DWI, msEPI-DWI, when performed at 5.0 T, demonstrated superior image quality and less anatomical distortion in a wide spectrum of brain diseases and showed promising diagnostic performance for LGGs and ACI. In the future, msEPI-DWI at 5.0 T could become clinically routine in the diagnosis and grading of brain disorders.

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5 T 磁共振成像中用于脑部疾病诊断的单点和多点扩散加权成像的比较。
背景:单次回声平面成像(ssEPI)的弥散加权成像(DWI)是检测急性脑损伤的重要工具,但存在图像失真的问题。多点回声平面成像(msEPI)是一种减少这种失真的技术。本研究旨在比较ssEPI-和msEPI-DWI在5.0 T下检测脑部疾病的图像质量和诊断效果:本研究回顾性分析了 2023 年 8 月至 2023 年 9 月在中国科学技术大学第一附属医院连续接受 5.0 T 的 ssEPI- 和 msEPI-DWI 的 107 例疑似脑部疾病患者的图像。两名放射科医生独立对图像质量进行分级并测量图像失真度。计算并比较ssEPI-和msEPI-DWI的信噪比、对比度-信噪比和表观弥散系数(ADC)。图像质量评分的比较采用 Wilcoxon 检验,其他连续变量的比较采用配对 t 检验。用曲线下面积(AUC)测量 ADC 值在区分病变和正常组织方面的诊断准确性:结果:图像质量评估和畸变分析表明,msEPI-DWI明显优于ssEPI-DWI(双侧Pvs:805.1±73.9;msEPI-DWI:1,196.2±355.6 vs. 757.3±98.0(单位:×10-6 mm))。0(单位:×10-6 mm2/s)],而急性脑梗死(ACI)病变的 ADC 值则显著较低[ssEPI-DWI:603.9±273.2 vs. 888.9±212.0;msEPI-DWI:538.0±281.2 vs. 905.0±188.9(单位:×10-6 mm2/s)](双侧 P≤0.003)。ssEPI-DWI(AUC =0.934;95% 置信区间 (CI):0.84-1.00)和 msEPI-DWI(AUC =0.944;95% 置信区间 (CI):0.86-1.00)检测 LGG 的 AUC 都非常好(双侧 PConclusions:与ssEPI-DWI相比,在5.0 T下进行的msEPI-DWI在广泛的脑部疾病中显示出更高的图像质量和更少的解剖失真,并对LGGs和ACI显示出良好的诊断性能。未来,5.0 T 的 msEPI-DWI 可能会成为临床上诊断和分级脑部疾病的常规方法。
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来源期刊
Quantitative Imaging in Medicine and Surgery
Quantitative Imaging in Medicine and Surgery Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
4.20
自引率
17.90%
发文量
252
期刊介绍: Information not localized
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