Diversity in U.S. Clinical Trials for Head and Neck Cancer: Are We Improving?

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-10-14 DOI:10.1002/hed.27943

Melani Camryn Zuckerman, Heather Ann Edwards

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Abstract

Background: This study assesses whether national initiatives undertaken to improve diversity in clinical trial enrollment have been successful within head and neck cancer (HNC) trials.

Methods: A retrospective analysis was conducted of HNC trials published on clinicaltrials.gov with start dates between 2000 and 2023. Demographic data for 8998 HNC trial enrollees was abstracted and analyzed to investigate potential demographic shifts.

Results: In the past 20 years, the percentage of White patients increased 6.1%, Asian patient population decreased 3.1%, and Black patient population increased 0.8%. Compared with previously published SEER data, HNC trials have significantly more White patients, fewer Black patients, and fewer Asian/Native-Hawaiian patients than HNC patients at large.

Conclusions: Despite efforts to increase diversity in HNC clinical trials in the United States, diversity has significantly decreased in the past 10 years. As current approaches are failing to show improvement, novel approaches to improving representation in clinical trials are necessitated.

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美国头颈癌临床试验的多样性：我们在进步吗？

背景：本研究评估了在头颈部癌症（HNC）试验中，国家采取的提高临床试验注册多样性的措施是否成功：本研究评估了在头颈癌（HNC）试验中，国家为提高临床试验注册多样性而采取的措施是否取得了成功：方法：研究人员对临床试验网（clinicaltrials.gov）上公布的开始日期在2000年至2023年之间的HNC试验进行了回顾性分析。对8998名HNC试验参与者的人口统计学数据进行了摘录和分析，以研究潜在的人口统计学变化：在过去20年中，白人患者的比例上升了6.1%，亚裔患者的比例下降了3.1%，黑人患者的比例上升了0.8%。与之前公布的 SEER 数据相比，HNC 试验中的白人患者、黑人患者和亚裔/夏威夷原住民患者人数均明显多于一般 HNC 患者：结论：尽管美国努力增加 HNC 临床试验的多样性，但在过去 10 年中，多样性已明显减少。由于目前的方法未能显示出改善效果，因此有必要采用新方法来提高临床试验的代表性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.