Changes in muscle quality and biomarkers of neuromuscular junctions and muscle protein turnover following 12 weeks of resistance training in older men.

IF 4.2 2区 医学 Q1 SPORT SCIENCES Biology of Sport Pub Date : 2024-10-01 Epub Date: 2024-07-08 DOI:10.5114/biolsport.2024.141064
Andrzej Mastalerz, Bizhan Hooshmand-Moghadam, Shadi Moazamigoudarzi, Fateme Golestani, Babak Hooshmand-Moghadam, Monika Johne, Krzysztof Maćkała, Katarzyna Lorenz, Ewelina Maculewicz
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Abstract

The present study aimed to investigate the effects of 12 weeks of resistance training (RT) on body composition [fat mass (FM), lean body mass (LBM)], muscle quality upper and lower (MQU, MQL), muscle size [cross sectional area (CSA), quadriceps cross-sectional area (QCSA)], biomarkers of neuromuscular junctions [C-terminal agrin fragment (CAF)], and muscle protein turnover [N-terminal peptide (P3NP), 3-methylhistidine (3MH), skeletal muscle-specific isoform of troponin T (sTnT)] in older men. Thirty elderly men (age 66.23 ± 0.57 years) were randomly divided into two groups: resistance training group (RT, n=15) and control group (CON, n=15). Participants in RT performed resistance training protocols with the intensity of 60% one-repetition maximum (3 × /week, 4 sets of the six exercise circuits). Blood samples were assessed before (pre-test) and after (post-test) a 12-week intervention. The ANCOVA (2 × 2; group × time; with the baseline variable as the covariate) revealed significant interaction effects; the greater increases for LBM (P < 0.001), CSA (P < 0.001), QCSA (P < 0.001), MQU (P < 0.05), MQL (P < 0.01), 3MH (P < 0.05) were noted in RT than CON, and greater decreases for FM (P < 0.001) and CAF (P < 0.001) in RT than CON. No interaction effect was found for P3NP and sTnT. The time effect was found for all variables besides P3NP in RT, but no time effect was revealed in CON. The 12-week RT was an effective strategy for improving the concentrations of neuromuscular junction biomarkers such as 3-MH and CAF in older adults, and may lead to favourable changes in body composition, muscle quality, and muscle size.

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老年男性接受 12 周阻力训练后肌肉质量、神经肌肉接头生物标志物和肌肉蛋白质周转的变化。
本研究旨在调查 12 周阻力训练(RT)对身体成分[脂肪量(FM)、瘦体重(LBM)]、上下肌肉质量(MQU、MQL)、肌肉大小[横截面积(CSA)、股四头肌横截面积(QCSA)]、神经肌肉接头生物标志物[C-末端鞘磷脂片段(CAF)]和肌肉蛋白质周转[N-末端鞘磷脂片段(CAF)]的影响、神经肌肉接头的生物标记物[C-末端麦角蛋白片段(CAF)]和肌肉蛋白质周转[N-末端肽(P3NP)、3-甲基组氨酸(3MH)、骨骼肌特异性肌钙蛋白 T 同工型(sTnT)]。30 名老年男性(年龄为 66.23 ± 0.57 岁)被随机分为两组:阻力训练组(RT,n=15)和对照组(CON,n=15)。阻力训练组的参与者进行强度为 60% 的单次重复最大值的阻力训练方案(3 × /周,六种运动循环 4 组)。在为期 12 周的干预前(测试前)和干预后(测试后)对血液样本进行了评估。方差分析(2 × 2;组别 × 时间;以基线变量为协变量)显示出显著的交互作用效应;RT 比 CON 的 LBM(P < 0.001)、CSA(P < 0.001)、QCSA(P < 0.001)、MQU(P < 0.05)、MQL(P < 0.01)、3MH(P < 0.05)的增加幅度更大,而 RT 比 CON 的 FM(P < 0.001)和 CAF(P < 0.001)的减少幅度更大。P3NP 和 sTnT 没有发现交互效应。在 RT 中,除 P3NP 外,所有变量均存在时间效应,但在 CON 中未发现时间效应。为期 12 周的 RT 是改善老年人神经肌肉接头生物标志物(如 3-MH 和 CAF)浓度的有效策略,并可能导致身体成分、肌肉质量和肌肉大小发生有利变化。
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来源期刊
Biology of Sport
Biology of Sport 生物-运动科学
CiteScore
8.20
自引率
12.50%
发文量
113
审稿时长
>12 weeks
期刊介绍: Biology of Sport is the official journal of the Institute of Sport in Warsaw, Poland, published since 1984. Biology of Sport is an international scientific peer-reviewed journal, published quarterly in both paper and electronic format. The journal publishes articles concerning basic and applied sciences in sport: sports and exercise physiology, sports immunology and medicine, sports genetics, training and testing, pharmacology, as well as in other biological aspects related to sport. Priority is given to inter-disciplinary papers.
期刊最新文献
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