Cancer-associated fibroblast cell surface markers as potential biomarkers or therapeutic targets in lung cancer.

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2024-09-10 eCollection Date: 2024-01-01 DOI:10.20517/cdr.2024.55
Samaneh Tokhanbigli, Mehra Haghi, Kamal Dua, Brian Gregory George Oliver
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Abstract

Cancer-associated fibroblasts (CAFs) are the vital constituent of the tumor microenvironment, and in communication with other cells, they contribute to tumor progression and metastasis. Fibroblasts are the proposed origin of CAFs, which are mediated by pro-inflammatory cytokines and the recruitment of immune cells akin to wound healing. Although various studies have identified different subpopulations of CAFs in lung cancer, the heterogeneity of CAFs, particularly in lung cancer, and their potential as a therapeutic target remain largely unknown. Notwithstanding CAFs were previously thought to have predominantly tumor-promoting features, their pro- or anti-tumorigenic properties may depend on various conditions and cell origins. The absence of distinct markers to identify CAF subpopulations presents obstacles to the successful therapeutic targeting and treatment of CAFs in cancer. Human clinical and animal studies targeting CAFs have shown that targeting CAFs exacerbates the disease progression, suggesting that subpopulations of CAFs may exert opposing functions in cancer progression. Therefore, it is essential to pinpoint specific markers capable of characterizing these subpopulations and revealing their mechanisms of function. The cell-specific surface markers of CAFs will serve as an initial step in investigating precise CAF subpopulations and their role in diagnosing and targeting therapy against cancer-promoting CAF subsets in lung cancer.

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作为肺癌潜在生物标记物或治疗靶点的癌症相关成纤维细胞表面标记物。
癌症相关成纤维细胞(CAFs)是肿瘤微环境的重要组成部分,它们与其他细胞相互作用,促进了肿瘤的发展和转移。成纤维细胞是 CAFs 的起源,它由促炎细胞因子和免疫细胞招募介导,类似于伤口愈合。尽管各种研究发现了肺癌中不同的 CAFs 亚群,但 CAFs 的异质性(尤其是在肺癌中)及其作为治疗靶点的潜力在很大程度上仍不为人所知。尽管 CAFs 以前被认为主要具有肿瘤促进特征,但它们的促或抗肿瘤特性可能取决于各种条件和细胞来源。由于缺乏识别 CAF 亚群的独特标记物,成功靶向和治疗癌症中的 CAFs 遇到了障碍。以 CAFs 为靶点的人体临床和动物研究表明,以 CAFs 为靶点会加剧疾病的进展,这表明 CAFs 亚群可能在癌症进展中发挥相反的功能。因此,必须找出能够描述这些亚群特征并揭示其功能机制的特异性标记物。CAFs的细胞特异性表面标记物将成为研究精确CAF亚群及其在诊断和针对肺癌促癌CAF亚群的治疗中的作用的第一步。
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