Karen Alpen, Robert J Maclnnis, Claire M Vajdic, John Lai, James G Dowty, Eng-Siew Koh, Elizabeth Hovey, Rosemary Harrup, Tuong L Nguyen, Shuai Li, David Joseph, Geza Benke, Pierre-Antoine Dugué, Melissa C Southey, Graham G Giles, Anna K Nowak, Katharine J Drummond, Daniel F Schmidt, John L Hopper, Miroslaw K Kapuscinski, Enes Makalic
{"title":"Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma.","authors":"Karen Alpen, Robert J Maclnnis, Claire M Vajdic, John Lai, James G Dowty, Eng-Siew Koh, Elizabeth Hovey, Rosemary Harrup, Tuong L Nguyen, Shuai Li, David Joseph, Geza Benke, Pierre-Antoine Dugué, Melissa C Southey, Graham G Giles, Anna K Nowak, Katharine J Drummond, Daniel F Schmidt, John L Hopper, Miroslaw K Kapuscinski, Enes Makalic","doi":"10.1158/2767-9764.CRC-24-0385","DOIUrl":null,"url":null,"abstract":"<p><strong>Significance: </strong>Further investigation of the potential susceptibility regions identified in our study may lead to a better understanding of glioma genetic risk and the underlying biological etiology of glioma. Our study suggests sex may play a role in genetic susceptibility and highlights the importance of sex-specific analysis in future glioma research.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555644/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/2767-9764.CRC-24-0385","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Significance: Further investigation of the potential susceptibility regions identified in our study may lead to a better understanding of glioma genetic risk and the underlying biological etiology of glioma. Our study suggests sex may play a role in genetic susceptibility and highlights the importance of sex-specific analysis in future glioma research.