Conserved perception of host and non-host signals via the a-pheromone receptor Ste3 in Colletotrichum graminicola.

IF 2.1 Q3 MYCOLOGY Frontiers in fungal biology Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.3389/ffunb.2024.1454633
Anina Yasmin Rudolph, Carolin Schunke, Daniela Elisabeth Nordzieke
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Abstract

Understanding the interactions between fungal plant pathogens and host roots is crucial for developing effective disease management strategies. This study investigates the molecular mechanisms underpinning the chemotropic responses of the maize anthracnose fungus Colletotrichum graminicola to maize root exudates. Combining the generation of a deletion mutant with monitoring of disease symptom development and detailed analysis of chemotropic growth using a 3D-printed device, we identify the 7-transmembrane G-protein coupled receptor (GPCR) CgSte3 as a key player in sensing both plant-derived class III peroxidases and diterpenoids. Activation of CgSte3 initiates signaling through CgSo, a homolog to the Cell Wall Integrity Mitogen-Activated Protein Kinase (CWI MAPK) pathway scaffold protein identified in other filamentous fungi, facilitating the pathogen's growth towards plant defense molecules. The NADPH oxidase CgNox2 is crucial for peroxidase sensing but not for diterpenoid detection. These findings reveal that CgSte3 and CWI MAPK pathways are central to C. graminicola's ability to hijack plant defense signals, highlighting potential targets for controlling maize anthracnose.

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Colletotrichum graminicola通过a-信息素受体Ste3感知宿主和非宿主信号的一致性。
了解真菌植物病原体与宿主根系之间的相互作用对于制定有效的病害管理策略至关重要。本研究调查了玉米炭疽病真菌禾谷壳霉对玉米根部渗出物的趋化反应的分子机制。结合缺失突变体的产生、病害症状发展的监测以及使用三维打印装置对趋化生长的详细分析,我们确定了 7 跨膜 G 蛋白偶联受体(GPCR)CgSte3 是感知植物源 III 类过氧化物酶和二萜类化合物的关键角色。CgSte3 的激活通过 CgSo(在其他丝状真菌中发现的细胞壁完整性丝裂原活化蛋白激酶(CWI MAPK)通路支架蛋白的同源物)启动信号传导,促进病原体向植物防御分子生长。NADPH 氧化酶 CgNox2 对过氧化物酶的感应至关重要,但对二萜类化合物的检测却不重要。这些发现揭示了 CgSte3 和 CWI MAPK 通路是禾谷镰孢菌劫持植物防御信号能力的核心,突出了控制玉米炭疽病的潜在目标。
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CiteScore
2.70
自引率
0.00%
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0
审稿时长
13 weeks
期刊最新文献
Metal tolerance of Río Tinto fungi. What lies behind the large genome of Colletotrichum lindemuthianum. Conserved perception of host and non-host signals via the a-pheromone receptor Ste3 in Colletotrichum graminicola. The yeast Wickerhamomyces anomalus acts as a predator of the olive anthracnose-causing fungi, Colletotrichum nymphaeae, C. godetiae, and C. gloeosporioides. Editorial: Co-morbidity of COVID 19 and fungal infections.
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