Advancements in therapeutic peptides: Shaping the future of cancer treatment

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-10-14 DOI:10.1016/j.bbcan.2024.189197
Xiaojie Chen , Zhiwei Zhao , Kyle Vaughn Laster , Kangdong Liu , Zigang Dong
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Abstract

In the evolving landscape of cancer treatment, therapeutic peptides are assuming to play an increasingly vital role. Although the number of peptide drugs available for clinical cancer treatment is currently limited, extensive preclinical research is underway, presenting a promising trajectory for the future. The collaborative efforts of natural anti-cancer peptides (ACPs) and synthetic ACPs, propelled by advancements in molecular biology and peptide chemistry, are steering remarkable progress in this domain. We explores the intricate mechanisms underlying the anti-cancer effects of these peptides. The exploration of innovative strategies, including cancer immunotherapy and advanced drug delivery systems, is likely to contribute to the increasing presenceuse of peptide drugs in clinical cancer care. Furthermore, we delve into the potential implications and challenges associated with this anticipated shift, emphasizing the need for continued research and development to unlock the full therapeutic potential of peptide drugs in cancer treatment.

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治疗肽的进步:塑造癌症治疗的未来。
在不断发展的癌症治疗领域,治疗肽正发挥着越来越重要的作用。虽然目前可用于临床癌症治疗的多肽药物数量有限,但广泛的临床前研究正在进行中,为未来的发展提供了良好的前景。在分子生物学和多肽化学进步的推动下,天然抗癌多肽(ACPs)和合成抗癌多肽的共同努力正在这一领域取得显著进展。我们探索了这些肽抗癌作用的复杂机制。对包括癌症免疫疗法和先进给药系统在内的创新策略的探索,很可能会促进肽类药物在临床癌症治疗中的应用。此外,我们还深入探讨了与这一预期转变相关的潜在影响和挑战,强调有必要继续进行研究和开发,以充分释放多肽药物在癌症治疗中的治疗潜力。
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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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