Nanotechnology in Drug Delivery: An Overview of Developing the Blood Brain Barrier.

Rasmita Dash, Subhankar Samanta, Bikash Ranjan Jena, Soumyaranjan Pradhan
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Abstract

The close connection between the brain microvascular endothelial cells (BMECs) that are enclosed within this barrier is the result of an intracellular junction, which is responsible for the constricted connection. The regulation and control of drug delivery systems both require nanoparticles, which are extremely small particles made up of a variety of materials, including polymers, metals, and other chemicals. Nanoparticles are a crucial component of the regulation and control of drug delivery systems. There is a possibility that nanomaterials composed of inorganic chemicals, such as gold nanoparticles, could be utilized in the treatment of neurodegenerative illnesses like Parkinson's disease. In addition to this, they are used as nano-carriers for the aim of distributing drugs to the region of the brain that is being targeted. There are a number of advantages that are easily apparent when compared to other methods of administering drugs for neurological diseases. The current review demonstrates both the advantages and disadvantages of utilizing a wide variety of nanomaterials for brain delivery, as well as the potential impact that this will have in the future on the safety and effectiveness of patient care.

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纳米药物传输技术:开发血脑屏障概述。
封闭在这层屏障中的脑微血管内皮细胞(BMECs)之间的紧密连接是细胞内连接的结果,而细胞内连接是收缩连接的原因。药物输送系统的调节和控制都需要纳米颗粒,纳米颗粒是由聚合物、金属和其他化学物质等多种材料组成的极小颗粒。纳米颗粒是药物输送系统调控的重要组成部分。由无机化学物质组成的纳米材料,如纳米金粒子,有可能被用于治疗帕金森病等神经退行性疾病。除此之外,它们还被用作纳米载体,目的是将药物分配到大脑的目标区域。与其他治疗神经系统疾病的给药方法相比,纳米载体的优势显而易见。本综述展示了利用各种纳米材料进行脑部给药的优缺点,以及这种方法在未来对患者护理的安全性和有效性可能产生的影响。
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