Bioinspired peptide/polyamino acid assemblies as quorum sensing inhibitors for the treatment of bacterial infections.

Abstract

Insufficient development of new antibiotics and the rise in antimicrobial resistance are putting the world at risk of losing curative medicines against bacterial infection. Quorum sensing is a type of cellular signaling for cell-to-cell communication that plays critical roles in biofilm formation and antimicrobial resistance, and is expected to be a new type of effective target for drug resistant bacteria. In this review we highlight recent advances in bioinspired peptide/polyamino acid assemblies as quorum sensing inhibitors across various microbial communities. In addition, existing obstacles and future development directions of peptide/polyamino acid assemblies as quorum sensing inhibitors were proposed for broader clinical applications and translations. Overall, quorum sensing peptide/polyamino acid assemblies could be vital tools against bacterial infection and antimicrobial resistance.