Advances in surface plasmon resonance for analyzing active components in traditional Chinese medicine.

Journal of pharmaceutical analysis Pub Date : 2024-10-01 Epub Date: 2024-04-26 DOI:10.1016/j.jpha.2024.100983
Jing Xie, Xian-Deng Li, Mi Li, Hong-Yan Zhu, Yan Cao, Jian Zhang, A-Jing Xu
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Abstract

The surface plasmon resonance (SPR) biosensor technology is a novel optical analysis method for studying intermolecular interactions. Owing to in-depth research on traditional Chinese medicine (TCM) in recent years, comprehensive and specific identification of components and target interactions has become key yet difficult tasks. SPR has gradually been used to analyze the active components of TCM owing to its high sensitivity, strong exclusivity, large flux, and real-time monitoring capabilities. This review sought to briefly introduce the active components of TCM and the principle of SPR, and provide historical and new insights into the application of SPR in the analysis of the active components of TCM.

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用于分析中药活性成分的表面等离子体共振技术的进展。
表面等离子体共振(SPR)生物传感器技术是研究分子间相互作用的一种新型光学分析方法。近年来,随着中药研究的不断深入,全面、特异地鉴定中药成分和目标相互作用已成为中药研究的重点和难点。SPR 具有灵敏度高、专属性强、通量大、实时监测等特点,已逐渐被用于中药活性成分的分析。本综述试图简要介绍中药的活性成分和 SPR 的原理,并对 SPR 在中药活性成分分析中的应用提供历史和新的见解。
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