Brain Lymphatics: Rediscovery and New Insights into Lymphatic Involvement in Diseases of Human Brains.

Lymphology Pub Date : 2024-01-01
M J Bartlett, R P Erickson, E B Hutchinson, R S Witte, M H Witte
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Abstract

The brain's lymphatic system is comprised of a glymphatic-meningeal-cervical lymphatic vessel pathway. The study of its mechanism and pathophysiology in neurodegenerative disease has been one of the most exciting topics in basic and translational neuroscience of the last decade. However, while there has been some debate about when the meningeal lymphatics were discovered, it cannot be denied that studies in preclinical models and humans in this century represent a monumental step forward in our understanding of how the brain removes metabolic waste, the role this system plays in neurodegenerative disease, and, most importantly, its potential as a novel therapeutic target. This is a summary of the history, functional anatomy, and role of the brain's lymphatics in neurodegenerative disease.

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脑淋巴管:脑淋巴管:人脑疾病中淋巴管参与的再发现和新见解》(Rediscovery and New Insights into Lymphatic Involvement in Diseases of Human Brains)。
大脑淋巴系统由淋巴管-脑膜-颈淋巴管通路组成。对其在神经退行性疾病中的作用机制和病理生理学的研究是近十年来基础和转化神经科学领域最激动人心的课题之一。然而,尽管人们对脑膜淋巴管何时被发现还存在争议,但不可否认的是,本世纪对临床前模型和人体的研究代表着我们在了解大脑如何清除代谢废物、这一系统在神经退行性疾病中扮演的角色,以及最重要的是其作为新型治疗靶点的潜力方面迈出了不朽的一步。本文概述了大脑淋巴管的历史、功能解剖以及在神经退行性疾病中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Brain Lymphatics: Rediscovery and New Insights into Lymphatic Involvement in Diseases of Human Brains. Imaging and Interventional Management of Lymphatic Disorders. Liver Lymphatic Anatomy and Its Role in Systemic Health and Disease. Looking Backward and Looking Forward: Revisiting "Clinical Usefulness of Thoracic Duct Cannulation". Lymphatic Imaging and Intervention in Central Lymphatic Disorders.
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