Periodontitis adversely affects lipoprotein subfractions – results from the cohort study SHIP-TREND

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes & metabolism Pub Date : 2024-10-11 DOI:10.1016/j.diabet.2024.101584

Pascal Basdorf , Thomas Kocher , Sebastian-Edgar Baumeister , Christiane Pink , Kathrin Budde , Astrid Petersmann , Nele Friedrich , Henry Völzke , Matthias Nauck , Birte Holtfreter

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Abstract

Aim

We aimed to investigate the medium-term associations of periodontitis and the number of missing teeth with serum lipoproteins and their plasma subfractions using follow-up data from the population-based Study of Health in Pomerania (SHIP-TREND).

Methods

A total of 2,058 participants with 7-year follow-up data underwent periodontal examinations, serum lipid panel tests, and proton nuclear magnetic resonance (¹H-NMR) spectroscopy of plasma lipoproteins and their subfractions. Generalized models with gamma distribution and loglink were used to analyze associations between periodontal variables and lipoproteins and their subfractions, adjusting for confounders using propensity score weighting.

Results

Periodontal variables were consistently associated with elevated follow-up serum levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol levels. When plasma lipoprotein subfractions were evaluated, periodontal variables were associated with elevated levels of triglycerides and cholesterol-enriched apolipoprotein B-containing lipoprotein particles, particularly small dense low-density lipoprotein, very-low-density lipoprotein and intermediate density lipoprotein. In addition, altered high-density lipoprotein particle composition was observed, suggesting potential functional changes.

Conclusion

This study provides evidence for causal effects of periodontitis on conventional serum lipids and plasma lipoprotein subfractions. As the underlying biological mechanisms are not fully understood, further research is needed.

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牙周炎对脂蛋白亚组分有不利影响--SHIP-TREND 队列研究的结果：牙周炎对脂蛋白亚组分有不利影响。

目的：我们旨在利用波美拉尼亚健康人群研究（SHIP-TREND）的随访数据，研究牙周炎和缺牙数量与血清脂蛋白及其血浆亚组分的中期关联：共有 2058 名参与者接受了为期 7 年的牙周检查、血清脂质全套检测以及血浆脂蛋白及其亚组分的质子核磁共振 (1H-NMR) 光谱分析。采用伽马分布和对数链接的广义模型分析牙周变量与脂蛋白及其亚组分之间的关系，并利用倾向得分加权法调整混杂因素：结果：牙周变量与随访血清中甘油三酯、总胆固醇和低密度脂蛋白胆固醇水平的升高持续相关。在评估血浆脂蛋白亚组分时，牙周变量与甘油三酯和富含胆固醇的载脂蛋白B脂蛋白颗粒水平升高有关，尤其是小密度低密度脂蛋白、极低密度脂蛋白和中密度脂蛋白。此外，还观察到高密度脂蛋白颗粒的组成发生了改变，这表明可能存在功能性变化：本研究为牙周炎对常规血清脂质和血浆脂蛋白亚组分的因果影响提供了证据。结论：本研究提供了牙周炎对常规血清脂质和血浆脂蛋白亚组分产生因果效应的证据，由于尚未完全了解其潜在的生物学机制，因此需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.20%

发文量

审稿时长

13 days

期刊介绍： A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.