Correlation of tumor budding with a novel and other established prognostic parameters in patients with invasive breast carcinoma.

Indian journal of pathology & microbiology Pub Date : 2024-10-17 DOI:10.4103/ijpm.ijpm_920_23

Neha D Borde, Yash M Thesiya, Meera S Mahajan, Chandrashekhar P Bhale

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引用次数: 0

Abstract

Context: Breast cancer is the most common malignancy among women. Established prognostic markers in breast carcinomas include tumor size, histologic grade, nodal status, lymphovascular invasion, perineural invasion, hormone receptor status, HER-2 status, and age.

Aim: To correlate peripheral tumor budding (pTB) with stromal tumor-infiltrating lymphocytes (sTILs) and established prognostic factors in invasive breast carcinoma.

Settings and design: It is a retrospective study conducted at multiple centers including a tertiary care center.

Materials and methods: 100 cases were included over a period of 2.5 years. All cases of invasive breast carcinoma (IBC) in which excision specimens with lymph node dissection were available were studied. Slides were reviewed for pTB and sTILs. Tumor budding of ≤20/10 hpf was considered low tumor budding, and >20 buds/10 hpf was considered high tumor budding. Tumor budding was correlated with age, tumor size, lymphovascular invasion, perineural invasion, tumor stage (pT, pN), stromal tumor-infiltrating lymphocytes, tumor grade, ductal carcinoma in situ, hormonal receptors, and HER2neu.

Statistical analysis: Fisher exact test and Chi-square test were used.

Results: We found that high tumor budding was seen in 34 cases and low tumor budding in 66 cases. There was a statistically significant association between high tumor budding and tumor size (P = 0.007), lymphovascular invasion (P < 0.001), perineural invasion (P = 0.004), tumor staging/pT (P = 0.006), nodal staging/pN (P = 0.001), and low sTILs (P < 0.001). However, the association of high tumor budding with parameters like age (P = 0.979), histological type (P = 0.243), tumor grade (P = 0.052), DCIS (P = 0.478), and ER (P = 0.633), and PR (P = 0.544), HER2Neu status (P = 0.171) was not significant.

Conclusion: This study suggests tumor budding score can be used as a prognostic indicator for breast cancer.

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浸润性乳腺癌患者肿瘤出芽与一种新的预后参数和其他已确定的预后参数之间的相关性。

背景：乳腺癌是女性最常见的恶性肿瘤。乳腺癌的既定预后指标包括肿瘤大小、组织学分级、结节状态、淋巴管侵犯、神经周围侵犯、激素受体状态、HER-2状态和年龄。目的：将外周肿瘤出芽（pTB）与基质肿瘤浸润淋巴细胞（sTILs）和浸润性乳腺癌的既定预后因素相关联：这是一项在多个中心（包括一家三级医疗中心）进行的回顾性研究。材料与方法：共纳入 100 例病例，历时 2.5 年。研究对象为所有可获得淋巴结清扫切除标本的浸润性乳腺癌（IBC）病例。对切片进行了 pTB 和 sTILs 检查。肿瘤萌芽≤20个/10 hpf被认为是低肿瘤萌芽，>20个/10 hpf被认为是高肿瘤萌芽。肿瘤出芽与年龄、肿瘤大小、淋巴管侵犯、神经周围侵犯、肿瘤分期（pT、pN）、基质肿瘤浸润淋巴细胞、肿瘤分级、导管原位癌、激素受体和HER2neu相关：采用费舍尔精确检验和卡方检验：结果：我们发现，34 个病例的肿瘤萌芽率较高，66 个病例的肿瘤萌芽率较低。高肿瘤萌发与肿瘤大小（P = 0.007）、淋巴管侵犯（P < 0.001）、神经周围侵犯（P = 0.004）、肿瘤分期/pT（P = 0.006）、结节分期/pN（P = 0.001）和低 sTILs（P < 0.001）之间有统计学意义。然而，肿瘤高出芽率与年龄（P = 0.979）、组织学类型（P = 0.243）、肿瘤分级（P = 0.052）、DCIS（P = 0.478）、ER（P = 0.633）、PR（P = 0.544）、HER2Neu状态（P = 0.171）等参数的关系并不显著：本研究表明，肿瘤萌芽评分可作为乳腺癌的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Indian journal of pathology & microbiology

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