Appearance time of blood in the brain as a possible indicator of oxygen extraction fraction: a feasibility study.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-10-16 DOI:10.1186/s13550-024-01160-z

Mitsumasa Murao, Nobuyuki Kudomi, Katsuya Mitamura, Takashi Norikane, Yuri Manabe, Yukito Maeda, Yuka Yamamoto, Tetsuhiro Hatakeyama, Yoshihiro Nishiyama

{"title":"Appearance time of blood in the brain as a possible indicator of oxygen extraction fraction: a feasibility study.","authors":"Mitsumasa Murao, Nobuyuki Kudomi, Katsuya Mitamura, Takashi Norikane, Yuri Manabe, Yukito Maeda, Yuka Yamamoto, Tetsuhiro Hatakeyama, Yoshihiro Nishiyama","doi":"10.1186/s13550-024-01160-z","DOIUrl":null,"url":null,"abstract":"Background: Imaging examination of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and metabolic rate of oxygen is crucial for understanding the normal functioning and pathophysiology of the brain. A recently developed method estimates the appearance time of cerebral blood (ATB) pixel-wise from the imaging examination of CBF alone. In this study, we aimed to test the potential of ATB as an indicator of OEF.Results: We retrospectively reviewed patients (n = 62) with suspected cerebrovascular disorders including steno-occlusive disease who underwent positron emission tomography (PET) with 15O-labelled tracers. Regarding the generated OEF and ATB images, a visual assessment was performed to test the consistency of the elevated OEF and delayed ATB. The OEF and ATB values and the absolute differences between their ipsilateral and contralateral sides were extracted and obtained for the entire hemisphere and the middle, anterior, and posterior cerebral arterial regions. Consistency was observed in 52 PET scans (83.9%) in visual assessment. The OEF and ATB values were moderately correlated (r = 0.553, p < 0.001), and the differences between their ipsilateral and contralateral sides were weakly correlated (r = 0.276, p < 0.001).Conclusion: Our results indicate the potential of ATB as an indicator of OEF.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11480264/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13550-024-01160-z","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Imaging examination of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and metabolic rate of oxygen is crucial for understanding the normal functioning and pathophysiology of the brain. A recently developed method estimates the appearance time of cerebral blood (ATB) pixel-wise from the imaging examination of CBF alone. In this study, we aimed to test the potential of ATB as an indicator of OEF.

Results: We retrospectively reviewed patients (n = 62) with suspected cerebrovascular disorders including steno-occlusive disease who underwent positron emission tomography (PET) with ¹⁵O-labelled tracers. Regarding the generated OEF and ATB images, a visual assessment was performed to test the consistency of the elevated OEF and delayed ATB. The OEF and ATB values and the absolute differences between their ipsilateral and contralateral sides were extracted and obtained for the entire hemisphere and the middle, anterior, and posterior cerebral arterial regions. Consistency was observed in 52 PET scans (83.9%) in visual assessment. The OEF and ATB values were moderately correlated (r = 0.553, p < 0.001), and the differences between their ipsilateral and contralateral sides were weakly correlated (r = 0.276, p < 0.001).

Conclusion: Our results indicate the potential of ATB as an indicator of OEF.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

将血液在大脑中的出现时间作为氧气提取率的可能指标：一项可行性研究。

背景：脑血流（CBF）、氧提取率（OEF）和氧代谢率的成像检查对于了解大脑的正常功能和病理生理学至关重要。最近开发的一种方法仅从 CBF 的成像检查中按像素估算脑血（ATB）的出现时间。在这项研究中，我们旨在测试 ATB 作为 OEF 指标的潜力：我们对疑似脑血管疾病（包括狭窄闭塞性疾病）患者（n = 62）进行了回顾性研究，这些患者接受了正电子发射断层扫描（PET），并使用了 15O 标记的示踪剂。对生成的 OEF 和 ATB 图像进行了目测评估，以检验 OEF 升高和 ATB 延迟的一致性。提取并获得了整个半球和大脑中、前、后动脉区域的 OEF 和 ATB 值及其同侧和对侧之间的绝对差异。52 次 PET 扫描（83.9%）的视觉评估结果一致。OEF 值与 ATB 值呈中度相关（r = 0.553，p 结论：OEF 值与 ATB 值呈中度相关（r = 0.553，p 结论）：我们的研究结果表明 ATB 可以作为 OEF 的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊