Enhancing Methodological Approaches for Studying Health Effects of High-Concentration THC Products.

IF 9.6 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH American journal of public health Pub Date : 2024-11-01 DOI:10.2105/ajph.2024.307724
Tianjing Li,George Sam Wang,Lisa Bero,Ashley Brooks-Russell,Gregory Tung,Jonathan M Samet
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Abstract

For public health protection, informed decision-making relies on having a robust foundation of evidence concerning risks and their prevention. Application of an evidence-based framework depends on the availability of pertinent, scientifically sound data generated by well-directed and valid research endeavors. In this essay, we address the current state of research in humans and the evidential base concerning high-concentration delta-9-tetrahydrocannabinol (delta-9-THC) products, which are readily available in the United States. Furthermore, we explore the intricate challenges faced in carrying out research on these products, which reflect the full range of study design issues: measurement of exposure and outcomes, confounding, selection bias, and the generalizability of findings. We offer recommendations to guide future research toward providing more informative evidence. By following these recommendations, researchers and funders on this emerging topic could move toward generating the valid and comprehensive evidence needed to effectively inform public health initiatives and guide policy decisions regarding high-concentration delta-9-THC products and their use. The urgency of generating such evidence cannot be overstated, given the widespread legalization and increasing availability and use of these products. (Am J Public Health. 2024;114(S8):S639-S644. https://doi.org/10.2105/AJPH.2024.307724).
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加强研究高浓度四氢大麻酚产品对健康影响的方法。
在公共卫生保护方面,明智的决策依赖于有关风险及其预防的强大证据基础。循证框架的应用取决于是否有相关的、科学上可靠的数据,这些数据是由方向明确的有效研究工作产生的。在这篇文章中,我们将讨论人类研究的现状以及有关高浓度δ-9-四氢大麻酚(δ-9-THC)产品的证据基础,这些产品在美国很容易买到。此外,我们还探讨了对这些产品进行研究时所面临的复杂挑战,这些挑战反映了一系列研究设计问题:暴露和结果的测量、混杂、选择偏差以及研究结果的普遍性。我们提出了一些建议,以指导未来的研究工作,从而提供更多翔实的证据。通过遵循这些建议,这一新兴课题的研究人员和资助者可以逐步形成所需的有效而全面的证据,为公共卫生活动提供有效信息,并指导有关高浓度 delta-9-THC 产品及其使用的政策决策。考虑到这些产品的广泛合法化以及越来越多的供应和使用,生成此类证据的紧迫性怎么强调都不为过。(Am J Public Health.2024;114(S8):S639-S644. https://doi.org/10.2105/AJPH.2024.307724).
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
American journal of public health
American journal of public health 医学-公共卫生、环境卫生与职业卫生
CiteScore
9.50
自引率
3.90%
发文量
1109
审稿时长
2-4 weeks
期刊介绍: The American Journal of Public Health (AJPH) is dedicated to publishing original work in research, research methods, and program evaluation within the field of public health. The journal's mission is to advance public health research, policy, practice, and education.
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