Associations between AHA's Life's Essential 8 and cognition in midlife and older adults.

IF 13 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-10-23 DOI:10.1002/alz.14294

Lindsay Master,Yuqi Shen,Alexa C Allan,May A Beydoun,Alan B Zonderman,Michele K Evans,Orfeu M Buxton,Alyssa A Gamaldo

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Abstract

INTRODUCTION This study evaluated the associations between Life's Essential 8 (LE8) and cognitive performance, and compared the strength of the relationships of Life's Simple 7 (LS7) and LE8 to cognition in midlife and older adults. METHODS Participants (N = 1539) were from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. Cross-sectional multivariable regression examined the associations between LE8 and cognition. Secondary analyses compared model performance between LE8 and LS7 measures on cognition from the same available sample. RESULTS Higher LE8 scores were associated with better global cognitive performance, working memory, and attention. The LS7 model outperformed the LE8 model on global cognitive performance, but the LE8 model outperformed the LS7 model for the working memory domain. DISCUSSION Better cardiovascular health (CVH) was associated with better cognitive performance among US middle-aged and older adults. However, the association between CVH and specific cognitive domains varies when using LE8 versus LS7. HIGHLIGHTS Cardiovascular health (CVH) is associated with cognitive performance. Life's Essential 8 (LE8) is a new construct to quantify CVH. Associations between LE8 and cognition were assessed. Higher LE8 was associated with better global cognitive performance. Higher LE8 was also associated with better working memory and attention.

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AHA 的 "人生必修 8 "与中老年人认知能力之间的关系。

简介：本研究评估了生活必备 8 项（LE8）与认知能力之间的关系，并比较了生活简单 7 项（LS7）和 LE8 与中老年人认知能力之间关系的强度。横截面多变量回归分析了LE8与认知能力之间的关系。结果LE8得分越高，整体认知能力、工作记忆和注意力越好。在整体认知能力方面，LS7 模型优于 LE8 模型，但在工作记忆领域，LE8 模型优于 LS7 模型。然而，在使用 LE8 和 LS7 时，CVH 与特定认知领域之间的关系有所不同。生活必备 8（LE8）是量化心血管健康的新概念。我们评估了 LE8 与认知能力之间的关联。LE8越高，整体认知能力越好。LE8 越高，工作记忆和注意力也越好。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.